EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
2.4.2.3 | uridine phosphorylase |
breast cancer cell |
negative correlation between UPase expression and the clinical outcome of breast cancer |
673810 |
2.4.2.30 | NAD+ ADP-ribosyltransferase |
breast cancer cell |
- |
736899 |
2.4.2.4 | thymidine phosphorylase |
breast cancer cell |
- |
684460, 684466, 686140, 688302, 705495 |
2.4.3.8 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase |
breast cancer cell |
- |
736910 |
2.4.3.8 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase |
breast cancer cell |
tissue samples of primary invasive breast cancer cases |
699089 |
2.4.3.9 | lactosylceramide alpha-2,3-sialyltransferase |
breast cancer cell |
- |
702982 |
2.5.1.60 | protein geranylgeranyltransferase type II |
breast cancer cell |
- |
658377 |
2.6.1.42 | branched-chain-amino-acid transaminase |
breast cancer cell |
- |
758728 |
2.6.1.42 | branched-chain-amino-acid transaminase |
breast cancer cell |
BCATc and BCATm are increased in breast cancer |
758657 |
2.6.1.52 | phosphoserine transaminase |
breast cancer cell |
immunohistochemical detection, in breast carcinoma PSAT1 expression is significantly associated with poor grade tumors and local relapse |
760151 |
2.6.1.52 | phosphoserine transaminase |
breast cancer cell |
transcriptional regulators TAZ/YAP activity positively correlates with transaminase expression in breast cancer patients |
759123 |
2.6.1.64 | glutamine-phenylpyruvate transaminase |
breast cancer cell |
transcriptional regulators TAZ/YAP activity positively correlates with transaminase expression in breast cancer patients |
759123 |
2.7.1.105 | 6-phosphofructo-2-kinase |
breast cancer cell |
- |
737973, 760902, 761915 |
2.7.1.107 | diacylglycerol kinase (ATP) |
breast cancer cell |
- |
761306 |
2.7.1.127 | inositol-trisphosphate 3-kinase |
breast cancer cell |
- |
760540 |
2.7.1.137 | phosphatidylinositol 3-kinase |
breast cancer cell |
- |
707976 |
2.7.1.137 | phosphatidylinositol 3-kinase |
breast cancer cell |
ER-positive breast cancer cells (UMB-1Ca) are grown as tumors in ovariectomized athymic nude mice |
686138 |
2.7.1.138 | ceramide kinase |
breast cancer cell |
- |
761664 |
2.7.1.138 | ceramide kinase |
breast cancer cell |
CERK expression is associated with an increased risk of recurrence in women with breast cancer |
737976 |
2.7.1.138 | ceramide kinase |
breast cancer cell |
tissue samples of primary invasive breast cancer cases |
699089 |
2.7.1.153 | phosphatidylinositol-4,5-bisphosphate 3-kinase |
breast cancer cell |
- |
707977, 710406 |
2.7.1.154 | phosphatidylinositol-4-phosphate 3-kinase |
breast cancer cell |
isozyme PI3K-C2beta is overexpressed in human breast cancer cell lines |
739216 |
2.7.1.183 | glycoprotein-mannosyl O6-kinase |
breast cancer cell |
- |
762066 |
2.7.1.32 | choline kinase |
breast cancer cell |
- |
671362, 672898, 723311, 759595, 760183 |
2.7.1.48 | uridine/cytidine kinase |
breast cancer cell |
analysis of the correlation between UCK2 gene expression and breast cancer survival, overview |
759533 |
2.7.1.67 | 1-phosphatidylinositol 4-kinase |
breast cancer cell |
non-specific infiltrating duct and infiltrating lobular carcinomas |
721967 |
2.7.1.74 | deoxycytidine kinase |
breast cancer cell |
- |
761315 |
2.7.1.91 | sphingosine kinase |
breast cancer cell |
- |
671356 |
2.7.1.94 | acylglycerol kinase |
breast cancer cell |
enzyme overexpression |
739046 |
2.7.10.1 | receptor protein-tyrosine kinase |
breast cancer cell |
- |
490103, 672895, 690303, 690447, 701713 |
2.7.10.1 | receptor protein-tyrosine kinase |
breast cancer cell |
EphA2 forms a complex with ErbB2, resulting in enhanced activation of Ras-MAPK signaling and RhoA GTPase |
693355 |
2.7.10.1 | receptor protein-tyrosine kinase |
breast cancer cell |
overexpression of EGFR-TK |
662724 |
2.7.10.1 | receptor protein-tyrosine kinase |
breast cancer cell |
overexpression of Her2-receptor |
661551 |
2.7.10.1 | receptor protein-tyrosine kinase |
breast cancer cell |
overexpression of Ron |
690303 |
2.7.10.2 | non-specific protein-tyrosine kinase |
breast cancer cell |
- |
490442, 490457, 490469, 661457, 662172, 662174, 676266, 691526 |
2.7.10.2 | non-specific protein-tyrosine kinase |
breast cancer cell |
breast cancer |
490443 |
2.7.10.2 | non-specific protein-tyrosine kinase |
breast cancer cell |
breast carcinomas |
490594 |
2.7.10.2 | non-specific protein-tyrosine kinase |
breast cancer cell |
breast tumours |
490596 |
2.7.10.2 | non-specific protein-tyrosine kinase |
breast cancer cell |
PYK2 |
673223 |
2.7.11.10 | IkappaB kinase |
breast cancer cell |
- |
676886 |
2.7.11.12 | cGMP-dependent protein kinase |
breast cancer cell |
- |
721503, 723796 |
2.7.11.13 | protein kinase C |
breast cancer cell |
shows higher levels of PKCalpha than normal breast tissue |
695064 |
2.7.11.16 | G-protein-coupled receptor kinase |
breast cancer cell |
- |
761893 |
2.7.11.17 | Ca2+/calmodulin-dependent protein kinase |
breast cancer cell |
- |
664865 |
2.7.11.17 | Ca2+/calmodulin-dependent protein kinase |
breast cancer cell |
differential expression of CaM-KI and CaM-KII in cell lines MCF-7 and MCF-10A |
664506 |
2.7.11.18 | myosin-light-chain kinase |
breast cancer cell |
- |
685933, 709713 |
2.7.11.20 | elongation factor 2 kinase |
breast cancer cell |
- |
721661, 741080, 760810, 761029, 761285 |
2.7.11.22 | cyclin-dependent kinase |
breast cancer cell |
- |
491470, 665497, 681873, 723656 |
2.7.11.24 | mitogen-activated protein kinase |
breast cancer cell |
- |
665638 |
2.7.11.25 | mitogen-activated protein kinase kinase kinase |
breast cancer cell |
high expression level of MEKK3 |
665600 |
2.7.12.2 | mitogen-activated protein kinase kinase |
breast cancer cell |
impaired expression of MKK4 |
682214 |
2.7.2.3 | phosphoglycerate kinase |
breast cancer cell |
moderate PGK1 expression |
682792 |
2.7.4.14 | UMP/CMP kinase |
breast cancer cell |
distribution of the enzyme expression in different cancer tissue samples, overview |
739700 |
2.7.7.14 | ethanolamine-phosphate cytidylyltransferase |
breast cancer cell |
- |
693518, 721513 |
2.7.7.19 | polynucleotide adenylyltransferase |
breast cancer cell |
- |
760831, 762420 |
2.7.7.43 | N-acylneuraminate cytidylyltransferase |
breast cancer cell |
- |
762081 |
2.7.7.49 | RNA-directed DNA polymerase |
breast cancer cell |
- |
692248 |
2.7.7.96 | ADP-D-ribose pyrophosphorylase |
breast cancer cell |
- |
761999, 762060 |
2.8.2.29 | [heparan sulfate]-glucosamine 3-sulfotransferase 2 |
breast cancer cell |
- |
662996, 761128 |
2.8.2.30 | [heparan sulfate]-glucosamine 3-sulfotransferase 3 |
breast cancer cell |
- |
739207 |
2.8.2.30 | [heparan sulfate]-glucosamine 3-sulfotransferase 3 |
breast cancer cell |
3-OST3A is epigenetically repressed in all breast cancer cell lines of a panel representative of distinct molecular subgroups, except in human epidermal growth factor receptor 2-positive (HER2+) sloan-kettering breast cancer (SKBR3) cells. Epigenetic mechanisms involved both DNA methylation and histone modifications, producing different repressive chromatin environments depending on the cell molecular signature |
762063 |
2.8.2.4 | estrone sulfotransferase |
breast cancer cell |
- |
671361, 676931, 691170, 691624, 693848, 701710, 701711, 761874 |
2.8.2.4 | estrone sulfotransferase |
breast cancer cell |
invasive, postmenopausal women |
674994 |
2.8.2.4 | estrone sulfotransferase |
breast cancer cell |
preinvasive and invasive cancer cells |
674994 |
2.8.2.4 | estrone sulfotransferase |
breast cancer cell |
reduced SULT1E1 expression in MCF-7 cells, but elevated SULT1E1 expression in breast tumour tissue, which also exhibits elevated E2 concentrations and increased Nrf2 expression as compared to the surrounding. Nrf2 is an oxidative stress responsive transcription protein, in situ expression analysis, overview |
761875 |
2.8.2.B6 | [heparan sulfate]-iuronate 2-sulfotransferase |
breast cancer cell |
- |
761128 |
3.1.26.5 | ribonuclease P |
breast cancer cell |
- |
691597 |
3.1.3.11 | fructose-bisphosphatase |
breast cancer cell |
- |
690771 |
3.1.3.11 | fructose-bisphosphatase |
breast cancer cell |
FBP1 is commonly upregulated in tumor tissues compared with non-tumor tissues regardless of histological type |
750008 |
3.1.3.16 | protein-serine/threonine phosphatase |
breast cancer cell |
elevated levels of PP5 protein occur in human breast cancer and suggest that PP5 over-expression may aid tumor progression |
691077 |
3.1.3.2 | acid phosphatase |
breast cancer cell |
- |
679089 |
3.1.3.48 | protein-tyrosine-phosphatase |
breast cancer cell |
- |
749498 |
3.1.3.5 | 5'-nucleotidase |
breast cancer cell |
- |
682217, 691078, 693298, 750845 |
3.1.3.66 | phosphatidylinositol-3,4-bisphosphate 4-phosphatase |
breast cancer cell |
primary, the enzyme is expressed in nonproliferative estrogen receptor-positive cells in the normal breast, and in estrogen receptor-positive, but not negative, breast cancer cell lines |
716766 |
3.1.3.86 | phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase |
breast cancer cell |
- |
750315, 751180 |
3.1.31.1 | micrococcal nuclease |
breast cancer cell |
high SND1 enzyme expression level |
729981 |
3.1.4.2 | glycerophosphocholine phosphodiesterase |
breast cancer cell |
- |
749764 |
3.1.4.39 | alkylglycerophosphoethanolamine phosphodiesterase |
breast cancer cell |
- |
696397, 703104, 728853 |
3.1.4.39 | alkylglycerophosphoethanolamine phosphodiesterase |
breast cancer cell |
overexpression of the enzyme is frequently observed in cancer tissues, such as breast cancer and glioblastoma |
728853 |
3.1.4.46 | glycerophosphodiester phosphodiesterase |
breast cancer cell |
the isozyme GDPD5 is significantly overexpressed in highly malignant estrogen receptor negative compared to weakly malignant estrogen receptor positive human breast cancer cells and breast tumors from patients, GDPD5 expression in tumors and correlation to choline containing metabolite levels, overview |
730482 |
3.1.6.1 | arylsulfatase (type I) |
breast cancer cell |
enzyme expression is unaltered in cancer tissue compared to nonmalignant tissue |
707966 |
3.1.6.2 | steryl-sulfatase |
breast cancer cell |
- |
682219, 706776 |
3.1.6.2 | steryl-sulfatase |
breast cancer cell |
expression of STS mRNA and STS activity are increased in malignant breast tissues compared with that in non-malignant tissues |
656640 |
3.1.6.2 | steryl-sulfatase |
breast cancer cell |
hormone-dependent |
714821 |
3.2.1.127 | 1,6-alpha-L-fucosidase |
breast cancer cell |
- |
699825 |
3.2.1.166 | heparanase |
breast cancer cell |
- |
693933, 731867, 732087 |
3.2.1.166 | heparanase |
breast cancer cell |
express high levels of endogenous heparanase-1 |
693320 |
3.2.1.35 | hyaluronoglucosaminidase |
breast cancer cell |
- |
703231 |
3.2.1.51 | alpha-L-fucosidase |
breast cancer cell |
- |
699825 |
3.3.2.11 | cholesterol-5,6-oxide hydrolase |
breast cancer cell |
enzyme ChEH is upregulated |
752861 |
3.4.11.1 | leucyl aminopeptidase |
breast cancer cell |
immunohistochemistry analysis of expression levels of LAP3 in breast cancer tissues. Expression of LAP3 in 105 cases of breast cancer is analyzed. The expression rate of LAP3 differs in various pathological histological grades, phenotypes, overview |
754242 |
3.4.11.3 | cystinyl aminopeptidase |
breast cancer cell |
N-methyl nitrosourea (NMU)-induced breast cancer |
753943 |
3.4.11.9 | Xaa-Pro aminopeptidase |
breast cancer cell |
- |
752870 |
3.4.13.9 | Xaa-Pro dipeptidase |
breast cancer cell |
- |
700612 |
3.4.13.9 | Xaa-Pro dipeptidase |
breast cancer cell |
breast cancer tissue shows high enzyme activity, reduced collagen content and decreased expression of beta1-integrins |
683557 |
3.4.13.9 | Xaa-Pro dipeptidase |
breast cancer cell |
increased prolidase activity in breast cancer tissue |
707010 |
3.4.14.9 | tripeptidyl-peptidase I |
breast cancer cell |
- |
678513 |
3.4.18.1 | cathepsin X |
breast cancer cell |
- |
710431 |
3.4.19.12 | ubiquitinyl hydrolase 1 |
breast cancer cell |
present in cancerous cells originating from tissues that do not normally express UCH-L1, including pancreatic cancer, colorectal cancer and invasive breast cancer |
752715 |
3.4.19.12 | ubiquitinyl hydrolase 1 |
breast cancer cell |
UCH-L3 mRNA level is significantly upregulated and UHCL1 mRNA level also show a non-significant increase in breast cancer tissue compared to adjacent normal breast tissue. Both UCH-L1 and UCH-L3 mRNA levels are significantly higher in high histological grade tumors than in low histological grade tumors. UCH-L1 mRNA level in tumors is approximately 10 times higher than that of UCH-L3 |
679040 |