EC Number   |
General Information |
Reference |
|---|
   7.2.2.19 | evolution |
the ubiquitous Na,K-ATPase and the gastric H,K-ATPase belong to the PIIC subgroup of the extensive class of P-type ATPases, which use ATP hydrolysis for active transport of cations. A lysine residue within the highly conserved center of the fifth transmembrane segment in PIIC-type ATPase alpha-subunits is uniquely found in H,K-ATPases instead of a serine in all Na,K-ATPase, EC 3.6.3.9, isoforms |
719901 |
| 7.2.2.19 | more |
direct H+/K+-ATPase inhibition by trimethyltin chloride in renal intercalated cells reduces urine K+ reabsorption and induces hypokalemia, overview |
713552 |
| 7.2.2.19 | physiological function |
distal colon absorbs K+ through a Na+-independent, ouabain-sensitive H+/K+-exchange, associated to an apical ouabain-sensitive H+/K+-ATPase |
711012 |
| 7.2.2.19 | physiological function |
enzyme activity is continuously required during biomineralization |
733694 |
| 7.2.2.19 | physiological function |
H+,K+-ATPase is responsible for the acidification of the gastric fluid |
734202 |
| 7.2.2.19 | physiological function |
possible involvement of the non-gastric H+/K+ ATPase ATP12A in prostate cancer |
719250 |
| 7.2.2.19 | physiological function |
the enzyme in stria vascularis contributes to pH regulation of cochlear endolymph but not to K+ secretion |
750207 |
| 7.2.2.19 | physiological function |
the enzyme plays an important role in drought tolerance in barley cultivar XZ5 |
750421 |
| 7.2.2.19 | physiological function |
the gastric proton pump, H+,K+-ATPase is the major membrane protein responsible for the gastric acid H+ secretion |
712894 |
| 7.2.2.19 | physiological function |
the H+-K+-ATPase alpha-subunit, HKalpha2, participates importantly in systemic acid-base homeostasis and defends against metabolic acidosis, showing pH-dependent regulation, overview. Regulatory role of pH-activated G protein-coupled receptor GPR4 in homeostatic regulation of HKalpha2 and acid-base balance |
718552 |
