EC Number   |
General Information |
Reference |
|---|
   7.2.2.12 | malfunction |
a prolonged accumulation of free zinc is observed in the DELTAzntA strain |
-, 720167 |
| 7.2.2.12 | malfunction |
enzyme deletion is associated with cytoplasmic Zn2+ accumulation, loss of secretory function and lactation failure. Enzyme deletion results in Zn2+-mediated degradation of phosphatase and tensin homolog, which impairs intercellular junction formation, prolactin receptor trafficking, and alveolar lumen development |
751101 |
| 7.2.2.12 | malfunction |
hma2 mutants have a significantly lower translocation ratio of Cd2+ and Zn2+ than the wild type enzyme |
720659 |
| 7.2.2.12 | physiological function |
disruption of transporter NpunR4017 results in a significant increase in zinc accumulation up to 24% greater than the wild-type, while cells overexpressing NpunR4107 accumulate 22% less than the wild-type. Accumulation of Zn2+ in ZntA-defective Escherichia coli overexpressing NpunR4017 is reduced by up to 21% |
733192 |
| 7.2.2.12 | physiological function |
HMA2 is not responsible for the uptake of heavy metals but is a major transporter of zinc and cadmium from roots to shoots |
720659 |
| 7.2.2.12 | physiological function |
isoform HMA4 is mainly responsible for xylem loading of heavy metals for root to shoot transport |
750670 |
| 7.2.2.12 | physiological function |
the enzyme is critical for appropriate mammary gland architecture. The interaction of the enzyme with V-ATPase critically mediates polarity establishment, alveolar development, and secretory function in the lactating mammary gland. The enzyme is required for the formation of acidified vesicles and secretion in mammary epithelial cells |
751101 |
| 7.2.2.12 | physiological function |
the enzyme is involved in Zn2+ and Cd2+ transport. Expression of HMA4 in tobacco (Nicotiana tabacum var. Xanthi) enhances Zn2+ translocation to the shoots only at 0.01 mM but not at 0.0005, 0.1 and 0.2 mM Zn2+. HMA4-expressing plants also show a decrease in cadmium uptake when exposed to 0.00025 and 0.005 mM Cd2+ |
720648 |
| 7.2.2.12 | physiological function |
the enzyme is responsible for zinc and cadmium translocation from roots to shoots in Arabidopsis thaliana |
751226 |
| 7.2.2.12 | physiological function |
the protein is involved in xylem loading of zinc. Expression of P1B-ATPase HMA4 facilitates root-to-shoot zinc translocation and induces zinc uptake in a Zn2+ supply-dependent manner. Enzyme expression increases zinc excess, triggers iron deficiency in leaves and transcriptional activation of Fe-uptake systems in roots. Moreover, enzyme expression causes zinc overload of the apoplast, which may contribute to enhanced zinc sensitivity of transgenic tomato plants |
720631 |
