EC Number |
General Information |
Reference |
---|
6.3.2.49 | evolution |
the enzyme belongs to the ATP-grasp superfamily |
-, 726581, 733347 |
6.3.2.49 | malfunction |
mutation of the bacD gene or transformation of the bacABC genes into a Bacillus subtilis D (ywfAbacABCDE) deletion mutant leads to the accumulation of anticapsin, which is 4fold higher after transformation of the bacABC genes into a bacD mutant |
-, 733219 |
6.3.2.49 | more |
conserved residue Arg328 is suggested to be a crucial residue for L-Ala recognition and catalysis. Residue Trp332 plays a key role in restricting the substrate specificity to smaller amino acids such as L-Ala. Trp332 mutants can alter the substrate specificity and activity depending on the size and shape of substituted amino acids, the positioning of the conserved Arg residue is important for enantioselective recognition of L-amino acids |
733347 |
6.3.2.49 | more |
molecular basis of the substrate specificity, overview, ATP- and dipeptide-binding site structures, overview |
-, 726581 |
6.3.2.49 | more |
physiological prevention of suicidal antibiotic effects, e.g. for enzyme-deficient strain GSB322 with plasmid pSB674(bacABCD), overview |
-, 733219 |
6.3.2.49 | physiological function |
involved in rhizocticin biosynthesis |
-, 702768 |
6.3.2.49 | physiological function |
the enzyme shows antibiotic activity against various indicator strains as Candida albicans CAP1-312, Escherica coli B, Escherichia coli K12, Proteus mirabilis, Proteus vulgaris, Sthapylococcus aureus, Streptomyces typhimurium, or Saccharomces cerevisiae |
-, 733219 |
6.3.2.49 | physiological function |
the enzyme shows antibiotic activity against various indicator strains as Escherica coli B, Escherichia coli K12, Proteus mirabilis, Proteus vulgaris, Staphylococcus aureus, Salmonella typhimurium, or Saccharomyces cerevisiae |
-, 733219 |
6.3.2.49 | physiological function |
the enzyme shows antibiotic activity against various indicator strains as Escherica coli B, Escherichia coli K12, Proteus mirabilis, Proteus vulgaris, Sthapylococcus aureus, Streptomyces typhimurium, or Saccharomces cerevisiae |
-, 733219 |