EC Number   |
General Information |
Reference |
|---|
   6.3.1.13 | malfunction |
mutants defective in mycothiol biosynthesis show mutations in genes coding for the glycosyltransferase (mshA) or the cysteine ligase (mshC). These mutants show low-level resistance to isoniazid but are highly resistant to ethionamide, mutations in mycothiol biosynthesis genes may contribute to isoniazid or ethionamide resistance across mycobacterial species |
726687 |
| 6.3.1.13 | malfunction |
Mycobacterium smegmatis mutants disrupted in mscR, coding for a dual function S-nitrosomycothiol reductase and formaldehyde dehydrogenase, and mshC, coding for a mycothiol ligase, EC 6.3.1.13, and lacking mycothiol (MSH), are more susceptible to S-nitrosoglutathione (GSNO) and aldehydes than wild-type. MSH is a cofactor for MscR, and both mshC and mscR are induced by GSNO and aldehydes. The transposon mutant, S24, disrupted in mshC, is most sensitive to killing by GSNO |
-, 745132 |
| 6.3.1.13 | metabolism |
mycothiol cysteine ligase (MshC) is a key enzyme in the mycothiol (MSH) biosynthesis, mycothiol biosynthesis and metabolic pathway, overview |
-, 744634 |
| 6.3.1.13 | metabolism |
the enzyme catalyzes the fourth step of a five step mycothiol, MSH, biosynthetic pathway |
-, 745132 |
| 6.3.1.13 | physiological function |
mycothiol and S-nitrosomycothiol reductase are required for normal biofilm formation in Mycobacterium smegmatis |
-, 745132 |
| 6.3.1.13 | physiological function |
mycothiol cysteine ligase (MshC) is a key enzyme in the mycothiol (MSH) biosynthesis. The function of MshC is irreplaceable |
-, 744634 |
