EC Number   |
General Information |
Reference |
|---|
   6.2.1.59 | physiological function |
a FadD26 mutant has impaired synthesis of phthiocerol dimycocerosates and is attenuated in BALB/c mice. The FadD26 mutant induces less pneumonia and larger delayed-type hypersensitivity reactions. It induces lower but progressive production of interferon-gamma, interleukin-4 and tumour necrosis factor-alpha. Used as a subcutaneous vaccine, the mutant induces a higher level of protection than does strain Bacille Calmette-Guérin (BCG). There is less tissue damage (pneumonia) and lower colony-forming units in the mice vaccinated with the FadD26 mutant compared to the findings in mice vaccinated with BCG |
-, 753308 |
| 6.2.1.59 | physiological function |
FadD26 is required for the production of phthiodiolone dimycocerosates but not of phenolic glycolipids. Disruption of FadD26 in Mycobacterium bovis BCG abolishes the production of phthiocerol dimycocerosate (DIM A) and of phthiodiolone dimycocerosate (DIM B) |
742482 |
| 6.2.1.59 | physiological function |
mutants lacking the Pps1-5 gene cluster are not able to produce phenolphthiocerol derivative, mycoside B, or phthiocerol dimycocerosates |
754047 |
| 6.2.1.59 | physiological function |
PpsA, the first-acting enzyme of a multisubunit noniterative polyketide synthase system is loaded with fatty acids by specific fatty acyl-AMP ligase FadD26 for biosynthesis of phthiocerol dimycocerosates. Deletion of fadD26 produces selective loss of phthiocerol dimycocerosates |
-, 742787 |
