EC Number |
General Information |
Reference |
---|
6.2.1.13 | evolution |
the enzyme is a member of the NDP-forming acyl-CoA synthetase enzyme superfamily |
744911 |
6.2.1.13 | malfunction |
amoebae lacking enzyme activity are unable to reestablish the acetyl-CoA/CoA ratio after an oxidative stress challenge |
744414 |
6.2.1.13 | malfunction |
gradual ACS gene silencing (49-93%) significantly decreases the acetate flux without affecting the levels of glycolytic metabolites and ATP in trophozoites. Amoebae lacking ACS activity are unable to reestablish the acetyl-CoA/CoA ratio after an oxidative stress challenge |
744414 |
6.2.1.13 | metabolism |
the enzyme is related to the phosphate-dependent fermentative glycolysis in Entamoeba histolytica. The end-products of carbohydrate catabolism in the parasite are ethanol and acetate, produced by the bifunctional aldehyde-alcohol dehydrogenase (ADHE) and ACS, respectively, overview |
744414 |
6.2.1.13 | metabolism |
the main role of the enzyme in the parasite energy metabolism is to recycle CoA for glycolysis to proceed under aerobic conditions |
744414 |
6.2.1.13 | more |
residue His252 is essential for enzymatic activity, substrate binding structure and mechanism, overview |
744911 |
6.2.1.13 | physiological function |
Archaeoglobus fulgidus strain 7324 converts starch to acetate via a modified Embden-Meyerhof pathway and acetyl-CoA synthetase (ADP-forming) |
-, 721449 |
6.2.1.13 | physiological function |
growth arrest is caused by elevated Acs, EC 6.2.1.1, activity, while overproduction of ADP-forming Ac-CoA synthesizing systems do not affect the growth behaviour of acetylation-deficient or acetylation-proficient strains |
716267 |