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EC Number General Information Commentary Reference
Show all pathways known for 6.2.1.1Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.1evolution the metalloprotein acetyl-coenzyme A synthase/carbon monoxide dehydrogenase, ACS/CODH, is a bifunctional metalloenzyme found in anaerobic archaea and bacteria that grow hemoautotrophically on CO or CO2, and is significant for biological carbon fixation and understanding the origin of life 714724
Show all pathways known for 6.2.1.1Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.1malfunction cyclic AMP inhibits the activity and promotes the acetylation of acetyl-CoA synthetase through competitive binding to the ATP/AMP pocket. cAMP directly binds to the enzyme and inhibits its activity in a substrate-competitive manner. cAMP binding increases SeAcs acetylation by simultaneously promoting Pat-dependent acetylation and inhibiting CobB-dependent deacetylation, resulting in enhanced SeAcs inhibition -, 745369
Show all pathways known for 6.2.1.1Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.1malfunction decreased isoform ACSS2 expression inhibits renal cell carcinoma cell migration and invasion 744665
Show all pathways known for 6.2.1.1Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.1malfunction deletion of individual and multiple subunits of acetyl-CoA synthetase decreases CoA release activity for several different CoA ester substrates. Deletion of acetyl-CoA synthetases I and II increases production of 3-hydroxypropionate by the metabolically-engineered hyperthermophile Pyrococcus furiosus (containing three enzymes from the CO2 fixation cycle of the thermoacidophilic archaeon Metallosphaerasedula) 725872
Show all pathways known for 6.2.1.1Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.1malfunction growth on 10 mM acetate causes an acs+ induction in a Salmonella enterica strain, that cannot acetylate, i.e. inactivate Acs, leads to growth arrest, a condition that correlates with a drop in energy charge in the acetylation-deficient strain, relative to the energy charge in the acetylation-proficient strain. Acs-dependent depletion of ATP, coupled with the rise in AMP levels, prevents the synthesis of ADP needed to replenish the pool of ATP 716267
Show all pathways known for 6.2.1.1Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.1malfunction in adult mice, attenuation of hippocampal isoform ACSS2 expression impairs long-term spatial memory 745887
Show all pathways known for 6.2.1.1Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.1metabolism acetyl-CoA synthase, a subunit of the bifunctional CO dehydrogenase/acetyl-CoA synthase, CODH/ACS, complex of Moorella thermoacetica requires reductive activation in order to catalyze acetyl-CoA synthesis and related partial reactions, including the CO/acetyl-CoA exchange reaction. Ferredoxin(II), which harbors two [4Fe-4S] clusters and is an electron acceptor for CODH, serves as a redox activator of ACS. Ferredoxin interfaces with an internal redox shuttle in acetyl-CoA synthase during reductive activation and catalysis. The midpoint reduction potential for the catalytic one-electron redoxactive species in the CO/acetyl-CoAexchange reaction is -511 mV. Incubation of ACS with Fd-II and CO leads to the formation of the NiFeC species. Mechanism, overview 714240
Show all pathways known for 6.2.1.1Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.1metabolism activation of weak organic acids by acyl-CoA synthetases is costly to cells, since it requires 2 mol of ATP per mol of substrate; 1 mol of ATP is consumed to activate the organic acid, while the second mol of ATP is needed to convert AMP to ADP, the immediate precursor of ATP. Further loss of energy resources during the course of the Acs reaction is caused by the hydrolysis of diphosphate to monophosphate through pyrophosphate phosphohydrolase, EC 3.6.1.1 716267
Show all pathways known for 6.2.1.1Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.1metabolism isoform ACSS2 retains acetate to maintain histone acetylation 744656
Show all pathways known for 6.2.1.1Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.1more growth arrest is caused by elevated Acs activity, while overproduction of ADP-forming Ac-CoA synthesizing systems, EC 6.2.1.13, do not affect the growth behaviour of acetylation-deficient or acetylation-proficient strains, effects of Acs on growth of different strains, also sirtuin-dependent protein acylation/deacylation system-defective strains, overview. Increased CoA biosynthesis partially alleviates the negative effect caused by high Acs activity, regulation, overview 716267
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