EC Number |
General Information |
Reference |
---|
6.1.1.22 | malfunction |
mutations of the mitochondrial asparaginyl-tRNA synthetase cause nonsyndromic deafness and leigh syndrome |
746169 |
6.1.1.22 | metabolism |
asparaginyl-tRNA synthetase is a member of the class-II aminoacyl-tRNA synthetases, and is responsible for catalyzing the specific aminoacylation of tRNAAsn with asparagine |
702933 |
6.1.1.22 | physiological function |
NARS is one of the important mediators of FGF2 induced survival signaling in osteoblasts through the activation of PI3K/Akt survival pathway |
702933 |
6.1.1.22 | physiological function |
the enzyme induces endothelial cell proliferation, promotes chemotaxis and induces ring formation and tube formation by EA.hy926 cells. The enzyme induces vasodilation in chick embryo chorioallantoic membranes |
746194 |
6.1.1.22 | physiological function |
the enzyme is a highly expressed excretory-secretory molecule which activates interleukin 8 (IL-8) receptors via extracellular domains that are different from those used by IL-8 |
728271 |