EC Number   |
General Information |
Reference |
|---|
   6.1.1.14 | malfunction |
Charcot-Marie-Tooth disease, CMT, type 2D, a hereditary axonal neuropathy, is caused by mutations in glycyl-tRNA synthetase |
706875 |
| 6.1.1.14 | malfunction |
enzyme knockdown decreases the global level of neddylation and causes cell cycle abnormality |
745876 |
| 6.1.1.14 | malfunction |
GARS gene mutations are involved in autosomal dominant motor distal neuronopathy/axonopathy, CMT2D/dSMA-V, and sporadic juvenile muscular atrophy of the distal upper extremity or Hirayama's disease, phenotype and mechanism, overview |
713735 |
| 6.1.1.14 | metabolism |
the essential enzyme for protein synthesis also plays a critical role in neddylation by specifically binding to NEDD8 and enhancing neddylation. The enzyme preferentially binds and protects Ubc12N8 and E, and regulates cell cycle progression |
745876 |
| 6.1.1.14 | physiological function |
glycyl-tRNA synthetase specifically binds to the poliovirus internal ribosome entry site to activate translation initiation |
728398 |
