EC Number   |
General Information |
Reference |
|---|
   5.6.1.1 | evolution |
the enzyme is a member of a family of AAA+ ATPases (ATPase associated with various cellular activities) |
735108 |
| 5.6.1.1 | malfunction |
cells overexpressing Kat60 display a disorganized array of fragmented microtubules and the overall length of microtubules appears to decrease with increasing levels of Kat60. Depletion of catalytic subunit Kat60 and regulatory subunit Kat80 causes minimal perturbation of steady-state alpha-tubulin levels in cells |
749052 |
| 5.6.1.1 | malfunction |
inhibition of katanin p60 results in incomplete cytokinesis by regression and thus caused the appearance of binucleate cells |
735108 |
| 5.6.1.1 | malfunction |
KATANIN 1 mutants, fra2, lue1 and ktn1-2 collectively display lower fertility and seed set in Arabidopsis. The lower fertility and seed set rates of fra2, lue1 and ktn1-2 mutants are correlated to abnormalities in the development of embryo proper and seed |
-, 747882 |
| 5.6.1.1 | malfunction |
mutations identified as a major cause of a genetic neurodegenerative condition termed hereditary spastic paraplegia |
718995 |
| 5.6.1.1 | malfunction |
point mutations or exon deletions in the microtubule-severing ATPase, spastin, are responsible for approximately 40% of cases of autosomal dominant hereditary spastic paraplegia |
720339 |
| 5.6.1.1 | malfunction |
rapid inactivation of katanin results in complete loss of ASPM-1 positive spindle poles. Strong loss-of-function mutants assemble apolar intersecting microtubule arrays, whereas weaker mutants assemble bipolar meiotic spindles that are longer than wild-type. Microtubule disassembly in enzyme point mutants, overview. Progressive loss of katanin leads to a progressive loss in the organization of pole-to-pole microtubule bundles, phenotypes |
734660 |
| 5.6.1.1 | malfunction |
variants show disorganized microtubules that lack focused spindle poles reminiscent of the Katanin loss-of-function phenotype, demonstrating that the microtubule-severing activity is essential for meiotic spindle assembly in Caenorhabditis elegans |
747634 |
| 5.6.1.1 | physiological function |
assembly of female meiotic spindles requires MEI-1 and MEI-2, which constitute the microtubule-severing AAA+ ATPase Katanin |
747634 |
| 5.6.1.1 | physiological function |
functional experiments indicate that spastin depletion results in reduced cell motility and higher cell proliferation of glioblastoma cell line T98G cells |
720295 |
