EC Number   |
General Information |
Reference |
|---|
   5.1.1.8 | evolution |
4-hydroxyproline 2-epimerase is a member of proline racemase family |
-, 748663 |
| 5.1.1.8 | malfunction |
a hypRE mutant grows with cis-4-hydroxy-D-proline but not with trans-4-hydroxy-L-proline, and it exhibits wild-type growth on succinate and proline, mutant complementation with the native smb20268 gene |
728328 |
| 5.1.1.8 | metabolism |
the enzyme is involved in the metabolic pathway of trans-4-hydroxy-L-proline |
748266 |
| 5.1.1.8 | metabolism |
the enzyme performs the first step of hydroxyproline catabolism, regulation, hyp cluster promoters are regulated by HypR, overview. cis-4-Hydroxy-D-proline is the effector that interacts with HypR and the results suggest a role of positive feedback in the regulation of hyp catabolism, as cis-4-hydroxy-D-proline (or a downstream catabolite) is a stronger inducer than the initial substrate trans-4-hydroxy-L-proline |
728328 |
| 5.1.1.8 | more |
the reaction mechanism requires two active site cysteines |
728328 |
| 5.1.1.8 | physiological function |
the enzyme 4-hydroxyproline 2-epimerase reversibly catalyse the interconversion of trans-4-hydroxy-L-proline and cis-4-hydroxy-D-proline. The Brucella proline racemase (PrpA) or hydroxyproline epimerase (BaHyPRE) also exhibit B-cell mitogenic properties thereby causing B-lymphocytes polyclonal activation and increase secretion of interleukin (IL)-10. Importance of PrpA in brucellosis |
-, 748663 |
| 5.1.1.8 | physiological function |
the enzyme is absolutely required for growth on trans-4-hydroxy-L-proline |
728328 |
