EC Number   |
General Information |
Reference |
|---|
    5.1.1.18 | evolution |
SerRs and AspRs are not separated by their racemase functions and form a serine/aspartate racemase family cluster based on phylogenetic analysis |
746724 |
| 5.1.1.18 | evolution |
SerRs and AspRs are not separated by their racemase functions and form a serine/aspartate racemase family cluster based on phylogenetic analysis, the organism has two paralogous genes, SerR and AspR. The presence of the triple serine loop region in both AspRs and SerRs leads to greater AspR activity while removing the triple serine loop region results in almost complete loss of AspR activity |
746724 |
| 5.1.1.18 | evolution |
the enzyme belongs to the fold-type II group of pyridoxal 5'-phosphate enzymes |
-, 748612 |
| 5.1.1.18 | evolution |
the enzyme from Zea mays belongs to the type II PLP-dependent enzymes and differs from the enzyme of a vancomycin-resistant bacterium |
746658 |
| 5.1.1.18 | evolution |
the eukaryotic serine racemase from Dictyostelium discoideum is a fold-type II pyridoxal 5'-phosphate-dependent enzyme |
726665 |
| 5.1.1.18 | malfunction |
D-Asp levels are significantly lower in the hippocampi and frontal cortices of SRR-knockout mice, approximately half the levels recorded from wild-type mice. These results are consistent with those from a previous study. In contrast, D-Asp abundance is not altered in the cerebellums or testes of SRR-knockout mice |
748126 |
| 5.1.1.18 | malfunction |
enzyme knockout mice show increased expression of involucrin and keratin 10 in the epidermis compared to wild-type mice |
-, 728085 |
| 5.1.1.18 | malfunction |
enzyme KO mutant mice show reduced D-serine contents, reduced N-methyl-D-aspartate receptor activity, and impaired learning and memory abilities, altered morphological features of brain of SR-KO mice, altered behaviur and neurodegeneration in KO mice, phenotypes of three SR-KO mouse strains, overview. Enzyme expression in the liver is upregulated in nSR-KO_ITC mice |
-, 726664 |
| 5.1.1.18 | malfunction |
HEK-293T cells expressing the wild-type enzyme and hyperactive mutant Q155D show resistance to staurosporine-induced apoptosis, compared with nontransfected HEK-293T cells and cells expressing the catalytically-dead enzyme mutant K56G. The wild-type enzyme-expressing cells also show a significant higher viability than the cells expressing hyperactive mutant Q155D enzyme mutant. Elevated phosphorylation levels of Bcl-2 at Ser70 and Akt at Ser473 and Thr308, which are related to cell survival, occur in the cells expressing wild-type enzyme and mutant Q155D, elevated levels of acetyl CoA and ATP in cells expressing the wild-type enzyme. Phenotypes, overview |
747183 |
| 5.1.1.18 | malfunction |
increased levels of enzyme-mediated D-serine production are associated with amyotrophic lateral sclerosis and Alzheimer's disease |
703286 |
