4.2.3.B67 | physiological function |
enzyme GrTPS2 catalyzes the first committed reaction in the biosynthesis of grindelic acid and related grindelane metabolites. With the formation of (13E)-labda-7,13-dien-15-yl diphosphate, GrTPS2 adds an additional function to the portfolio of monofunctional class II diTPSs, which catalytically most closely resembles the bifunctional labda-7,13E-dien-15-ol synthase of the lycopod Selaginella moellendorffii. Grindelia robusta produces large quantities of these diterpenoids that are secreted through specialized ducts and glandular trichomes as a resinous exudate that covers the surface of the aerial parts of the plant. Among the diterpenoids, grindelic acid is the predominant metabolite and most abundant in resin with 9, 37, and 81fold higher levels as compared with flowers, leaves, and stems, respectively |
743471 |