EC Number   |
General Information |
Reference |
|---|
    4.2.1.78 | evolution |
evolutionary origin of the NCSI gene subfamily encoding norcoclaurine synthase |
749319 |
| 4.2.1.78 | metabolism |
norcoclaurine synthase, NCS, catalyzes the first committed step in the biosynthesis of benzylisoquinoline alkaloids, exclusive role of PR10/Bet v1-type NCS enzymes, overview |
716518 |
| 4.2.1.78 | metabolism |
the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis |
749327 |
| 4.2.1.78 | metabolism |
the enzyme catalyzes the stereoselective Pictet-Spengler reaction between dopamine and 4-hydroxyphenylacetaldehyde as a step of benzylisoquinoline alkaloid synthesis in plants |
747310 |
| 4.2.1.78 | metabolism |
the enzyme is a Pictet-Spenglerase that catalyzes a step in plant benzylisoquinoline alkaloid metabolism, a compound family that includes bioactive natural products such as morphine |
747130 |
| 4.2.1.78 | metabolism |
the enzyme is involved in biosynthesis of benzylisoquinoline alkaloids |
749319 |
| 4.2.1.78 | metabolism |
the enzyme is involved in the biosynthesis of benzylisoquinoline |
747372 |
| 4.2.1.78 | metabolism |
the enzyme is involved in the biosynthetic of benzylisoquinoline |
747372 |
| 4.2.1.78 | more |
amino acid sequence comparisons of NCSs from different species, phylogenetic tree, overview |
716518 |
| 4.2.1.78 | physiological function |
key steps in the biotransformation consist of the oxidative decarboxylation of tyrosine by stoichiometric amounts of sodium hypochlorite in order to generate 4-hydroxyphenylacetadehyde, followed by the addition of enzyme and dopamine substrate in the presence of ascorbate, a necessary ingredient in order to avoid oxidation of the catechol moiety |
715141 |
