EC Number   |
General Information |
Reference |
|---|
    4.2.1.24 | malfunction |
delta-ALA-D activity is inhibited in diabetes mellitus, which can result in aminolevulinic acid accumulation that, under physiological relevant conditions, can have pro-oxidant effects. delta-ALA-D activity shows to be correlated with lipid profile indicating that disturbances in lipoproteins metabolism may affect the enzymatic activity |
714758 |
| 4.2.1.24 | malfunction |
delta-aminolevulinic acid dehydratase-deficient porphyria is a rare enzymatic deficiency of the heme biosynthetic pathway |
713748 |
| 4.2.1.24 | metabolism |
delta-aminolevulinic acid dehydratase is involved in the heme biosynthetic pathway |
713748 |
| 4.2.1.24 | metabolism |
PBGS is a key enzyme in heme biosynthesis |
716012 |
| 4.2.1.24 | metabolism |
the enzyme catalyses the second step in heme biosynthesis |
728984 |
| 4.2.1.24 | physiological function |
a lesion mimic mutant defective in 5-aminolevulinic acid dehydratase, exhibits necrotic leaf damage and enhanced disease resistance. The mutant exhibits an overaccumulation of the 5-aminolevulinic acid, elevated levels of reactive oxygen species and salicylic acid, along with constitutive expression of pathogenesis-related genes and enhanced resistance to the Verticillium dahliae infection |
748990 |
| 4.2.1.24 | physiological function |
delta-aminolevulinate dehydratase is a cytosolic sulfhydryl-containing enzyme that catalyzes the condensation of two molecules of aminolevulinic acid in order to form porphobilinogen, which is the precursor of heme, cytochromes and cobalamines. ALAD plays a role in proteasome S26 activity, which it increases by 75%, overview. The 26S proteasome, a protein complex formed by 32 subunits, performs multiple important proteolytic activities in the cell interacting with the ubiquitination system |
714924 |
| 4.2.1.24 | physiological function |
infection with Trypanosoma evansi is associated with haematocrit, serum levels of iron and zinc and lipid peroxidation. Increased activity of delta-ALA-D in blood occurs in response to the anaemia in remission as heme synthesis is enhanced, iron reduction has a negative correlation with the activity of delta-ALA-D |
-, 716429 |
| 4.2.1.24 | physiological function |
it is shown that autologous and allogeneic bone marrow transplantation are associated with oxidative stress and that delta-ALA-D activity is a reliable marker for oxidative stress in bone marrow transplantation patients |
702882 |
| 4.2.1.24 | physiological function |
PBGS is a key enzyme in heme biosynthesis that catalyzes the formation of porphobilinogen from two 5-aminolevulinic acid molecules via formation of intersubstrate C-N and C-C bonds |
716012 |
