EC Number   |
General Information |
Reference |
|---|
  4.2.1.136 | evolution |
the enzyme belongs to the PF01256 family |
730977 |
| 4.2.1.136 | malfunction |
ablation of the Arabidopsis dehydratase gene raises seedling levels of all NADHX forms by 20 to 40fold, and levels of one NADPHX form by 10 to 30fold |
-, 728528 |
| 4.2.1.136 | malfunction |
the Bacillus subtilis 168 osmosensitive mutant, defective in the yxkO gene, gene yxkO knockout phenotype, overview. Changes in the protein value caused by yxkO disruption are also recorded for GroEL. In the mutant, the increase of protein level occurred in non-stressed conditions, as well when compared to the wild-type due to extension of the lag phase and the decline of the renewing of isocitrate dehydrogenase levels in the mutant according to wild-type after stress exposure, which denotes to failure of stress adaptation and triggers increased levels of GroEL as a result of the devastating effects of both stresses on cellular proteins. Identification of differences in protein levels under osmotic stress and ethanol stress, overview |
-, 749142 |
| 4.2.1.136 | metabolism |
plants have a canonical two-enzyme NAD(P)HX repair system that is directed to three subcellular compartments via the use of alternative translation start sites |
-, 728528 |
| 4.2.1.136 | more |
catalytic residue is D216 |
730977 |
| 4.2.1.136 | more |
catalytic residue is D431 |
730977 |
| 4.2.1.136 | physiological function |
NADH and NADPH undergo spontaneous and enzymatic reactions that produce R and S forms of NAD(P)H hydrates [NAD(P)HX], which are not electron donors and inhibit various dehydrogenases. The NAD(P)HX dehydratase is able to reconvert (S)-NAD(P)HX to NAD(P)H in an ATP-dependent manner |
-, 728528 |
| 4.2.1.136 | physiological function |
the regulatory adaptive system called general stress response (GSR) is dependent on the SigB transcription factor in Bacillus sp.. The GSR is one of the largest regulon in Bacillus sp., including about 100 genes. The yxkO gene (encoding a putative ribokinase) is recently assigned in vitro as an ADP/ATP-dependent NAD(P)H-hydrate dehydratase and belongs to the SigB operon. YxkO has an impact on the activity of SigB-dependent Pctc promoter and adaptation to osmotic and ethanol stress and potassium limitation respectively. The enzyme might play a significant role in the survival of stressed cells |
-, 749142 |
