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Results 1 - 6 of 6
EC Number General Information Commentary Reference
Show all pathways known for 4.1.99.22Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.22malfunction cyclic pyranopterin monophosphate (cPMP) is strongly decreased in cnx2 mutants. Phenotype of T-DNA insertion mutant line cnx2-1, the cnx2-1 knockout is seedling-lethal but growth is rescued by ammonia, overview. Mutant xd22 has a mutation in CNX2 affecting the proximal FeS cluster loop. With hypoxanthine as a substrate, no activity is detectable in leaves from cnx2-2 plants. Nitrate reductase activity in leaf extract from cnx2-2 is 55% compared to wild-type values. Genetic complementation and strongly decreased activities of Moco enzymes show that the mutation in xd22 (R88Q) is located in CNX2, line cnx2-2, encoding the first step in Moco biosynthesis. The cnx2-2 mutation is not a knockout allele and growth is rescued by ammonia. Crosses between heterozygous cnx2-1 CNX2 and homozygous cnx2-2 plants give F1 offspring in two phenotype categories: seedlings with wild-type appearance corresponding to cnx2-1 CNX2 and small chlorotic seedlings that are genotyped as cnx2-1 cnx2-2 -, 747034
Show all pathways known for 4.1.99.22Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.22metabolism molybdenum cofactor (Moco) biosynthesis starts with the condensation of GTP into cyclic pyranopterin monophosphate (cPMP) by the consecutive action of GTP 3',8-cyclase and cPMP synthase, encoded by CNX2 and CNX3 in plants, respectively, pathways for FeS cluster assembly and Moco biosynthesis in Arabidopsis thaliana, overview -, 747034
Show all pathways known for 4.1.99.22Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.22metabolism the enzyme MoaA catalyzes the fist step of molybdenum cofactor (Moco) biosynthesis -, 747120
Show all pathways known for 4.1.99.22Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.22physiological function the GG motif is essential for the activity of MoaA to produce (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate from GTP, and synthetic peptides corresponding to the C-terminal region of wild-type MoaA rescue the GTP 3',8-cyclase activity of the GG-motif mutants. The C-terminal tail containing the GG motif interacts with the SAM-binding pocket of MoaA, and is essential for the binding of SAM and subsequent radical initiation -, 738455
Show all pathways known for 4.1.99.22Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.22physiological function the MoaA protein is involved in the conversion of 5'-GTP to cyclic pyranopterin monophosphate in the fist step of molybdenum cofactor (Moco) biosynthesis -, 747120
Show all pathways known for 4.1.99.22Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.22physiological function the physiological function of MoaA is the conversion of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate (GTP 3?,8-cyclase), and that of MoaC is to catalyze the rearrangement of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate into cyclic pyranopterin -, 739551
Results 1 - 6 of 6