   4.1.99.20 | physiological function |
3-amino-4-hydroxybenzoic acid (3,4-AHBA) is a metabolic intermediate of grixazone biosynthesis in Streptomyces griseus and is synthesized by the activities of the enzymes GriI and GriH, which are encoded by griI and griH, respectively. GriI catalyzes an aldol condensation reaction between L-aspartate-4-semialdehyde and dihydroxyacetone phosphate, and GriH converts the resulting C7 metabolite into 3,4-AHBA. Through this two-step reaction, these two enzymes can produce an aromatic ring from C4 (L-aspartate-4-semialdehyde) and C3 (dihydroxyacetone phosphate) primary metabolites, whereas most aromatic compounds, including aromatic amino acids, are formed in a multistep reaction via the shikimate pathway |
747305 |
