EC Number   |
General Information |
Reference |
|---|
   4.1.2.9 | evolution |
phylogenetic analysis of bacterial and fungal phosphoketolases, fungal phosphoketolases are of bacterial origin |
703478 |
| 4.1.2.9 | malfunction |
disruption of the putative phosphoketolase gene in wild-type Synechocystis leads to a deficiency in acetate production in the dark, indicative of a contribution of the phosphoketolase pathway to heterotrophic metabolism |
748753 |
| 4.1.2.9 | metabolism |
key enzyme in pentose metabolism |
746964 |
| 4.1.2.9 | metabolism |
lactic acid bacteria produce lactate, acetate, ethanol and carbon dioxide using the phosphoketolase pathway. When fructose is present, the redox balance can be maintained by the production of mannitol, which enables the formation of acetate instead of ethanol. The phosphoketolase has a lower energy yield in the form of ATP compared to that of the Embden-Meyerhof pathway (2 ATP for the Embden-Meyerhof pathway vs. only 1 for the phosphoketolase pathway) but it is used by lactic acid bacteria to ferment pentoses |
-, 748374 |
| 4.1.2.9 | metabolism |
members from the order Bifidobacteriales differ from all other organisms in using a unique pathway for carbohydrate metabolism, known as the "bifid shunt", which utilizes the enzyme phosphoketolase to carry out the phosphorolysis of both fructose-6-phosphate and xylulose-5-phosphate. The existence of the bifid shunt allows bifidobacteria to produce more ATP from carbohydrates than through other conventional pathways. In contrast to bifidobacteria, the phosphoketolases found in other organisms (referred to XPK) are able to metabolize primarily xylulose-5-phosphate and show very little activity towards fructose-6-phosphate |
749102 |
| 4.1.2.9 | metabolism |
mutation of the gene encoding phosphoketolase almost completely abolishes flux through the pentose phosphoketolase pathway during growth on arabinose and results in decreased acetate/butyrate ratios |
748611 |
| 4.1.2.9 | metabolism |
the enzyme catalyzes the formation of acetyl-phosphate, which enzymatically can be converted into acetyl-CoA key precursor in central carbon metabolism |
746713 |
| 4.1.2.9 | metabolism |
the enzyme catalyzes the formation of acetyl-phosphate, which enzymatically can be converted into acetyl-CoA-A key precursor in central carbon metabolism |
746713 |
| 4.1.2.9 | metabolism |
the enzyme is indispensable for acetate production in the dark in all tested genetic backgrounds and nutrient conditions, which supports its physiological role as a phosphoketolase in the central carbon metabolism |
748753 |
| 4.1.2.9 | metabolism |
the enzyme is involved in pentose phosphoketolase pathway. This pathway has a primary role in arabinose metabolism of Clostridium acetobutylicum |
748611 |
