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EC Number General Information Commentary Reference
Show all pathways known for 4.1.2.55Display the word mapDisplay the reaction diagram Show all sequences 4.1.2.55physiological function comparison of the catalytic efficiency (kcat/KM) for 2-dehydro-3-deoxy-D-gluconate (1.1 mM/s) and 2-dehydro-3-deoxy-D-gluconate 6-phosphate (643 mM/s) suggests that cleavage of the phosphorylated substrate would be significantly favoured in a situation where both compounds are present. If the 2-dehydro-3-deoxy-D-gluconate kinase is present and active then central metabolism will occur via the part-phosphorylative route.The Km of the kinase for ATP of 2.8 mM is high compared to the likely intracellular concentration, and it is possible that the non-phosphorylative pathway would be favoured under starvation conditions, which could produce pyruvate to allow the citric acid cycle to function without ATP input. regardless of whether Sulfolobus solfataricus uses the part-phosphorylative or the non-phosphorylative Entner-Doudoroff pathway, then the same enzymes can be used for the metabolism of glucose and its C4 epimer galactose 719488
Show all pathways known for 4.1.2.55Display the word mapDisplay the reaction diagram Show all sequences 4.1.2.55physiological function the enzyme is involved in the non-phosphorylated Entner-Doudoroff pathway of glucose oxidation 677304
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