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3.6.1.66
malfunction
enzyme deficiency results in cell growth suppression and DNA instability. Both growth suppression and accumulation of single-strand breaks in nuclear DNA of enzyme-deficient cells depended on MLH1/PMS2
758375
3.6.1.66
physiological function
the enzyme hydrolyzes the non-canonical nucleotides, dITP and XTP and may have a major role in preventing mutations caused by incorporation of dITP and XTP formed spontaneously in the nucleotide pool into DNA
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723282
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