EC Number   |
General Information |
Reference |
|---|
   3.6.1.6 | evolution |
GS52 is a member of the NTPDase/apyrase family |
720736 |
| 3.6.1.6 | evolution |
the enzyme is a family member of the COG1839 family, defined as adenosine-specific kinase family based on structural analysis and the adenosine-binding ability |
-, 756218 |
| 3.6.1.6 | evolution |
the SA1684 gene product carries theDUF402domain, which is found in RNA-binding proteins, and has amino acid sequence similarity with a nucleoside diphosphatase, Streptomyces coelicolor SC4828 protein |
-, 757160 |
| 3.6.1.6 | evolution |
the seven member Arabidopsis apyrase family contains representatives in each clade and are clustered into the AtAPY1-2 clade I (GDA1-like), the AtAPY3-6 (clade II) and AtAPY7 in clade III. The clade I (GDA-like) Arabidopsis members (AtAPY1 andAtAPY2) form a distinct clade with the other characterized plant apyrases, human apyrases and the yeast GDA1 enzyme. The protein structure of the seven Arabidopsis apyrase proteins outline the apyrase conserved domain GDA1_CD39 and predicted transmembrane helices |
755996 |
| 3.6.1.6 | malfunction |
enzyme knock-out mice recapitulate the desbuquois dysplasia type 1 phenotype |
751452 |
| 3.6.1.6 | malfunction |
immunochemical and genetic suppression of AtAPY1 and AtAPY2 results in an increase in extracellular ATP |
755996 |
| 3.6.1.6 | malfunction |
macrophages isolated from NTPDase1-null mice are devoid of all ADPase and most ATPase activities when compared with wild type macrophages. NTPDase1-null macrophages exposed to millimolar concentrations of ATP are more susceptible to cell death, release more interleukin-1beta and interleukin-18 after TLR2 or TLR4 priming, and incorporate the fluorescent dye Yo-Pro-1 more efficiently (suggestive of increased pore formation) than wild type cells |
711898 |
| 3.6.1.6 | malfunction |
nucleotide hydrolysis is impaired in the wall of Entpd1-/- vessels compared with Entpd1+/+ aortas, which display significant ADPase and ATPase activity |
-, 719196 |
| 3.6.1.6 | malfunction |
the mean glial Ca2+ response to ATP was significantly larger in the presence of an NTPDase inhibitor |
-, 718541 |
| 3.6.1.6 | malfunction |
the SA1684-deletion mutant exhibits drastically decreased virulence in a silkworm (Bombyx mori) infection model, in which the LD50 against silkworm larvae is more than 10times that of the parent strain. The SA1684-deletion mutant also exhibits decreased exotoxin production and colony-spreading ability. Introduction of wild-type SA1684 to the SA1684-deletion mutant restores the hemolysin production, nuclease production, and the colony-spreading activity |
-, 757160 |
