EC Number |
General Information |
Reference |
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3.5.4.1 | metabolism |
human mitochondrial and nuclear DNA are edited by APOBEC3A. The degree of editing is much greater in patients lacking the uracil DNA-glycolyase gene |
720926 |
3.5.4.1 | physiological function |
for woodchuck hepatitis virus mAPOBEC3 is operative |
720241 |
3.5.4.1 | physiological function |
mHBV (mouse transgenic model of HBV replication) is edited in vivo by mAPOBEC1 (mA1) and not mAPOBEC3 |
720241 |
3.5.4.1 | physiological function |
porcine A3 is tested toward their antiretroviral activity against porcine endogenous retrovirus (PERV) and murine leukemia virus (MuLV) using novel single-round reporter viruses. The porcine A3Z2, A3Z3 and A3Z2-Z3 mRNAs are packaged into PERV particles and inhibit PERV replication in a dose-dependent manner. The antiretroviral effect correlate with editing by the porcine A3s with a trinucleotide preference for 5' TGC for A3Z2 and A3Z2-Z3 and 5' CAC for A3Z3 |
720347 |
3.5.4.1 | physiological function |
residues His62, Cys91, and Cys94 are very important in coordinating the zinc cation. The bound water molecule and Glu64 are crucial in the formation of the reactant-metal binding state, the subsequent chemical reaction, and the cleavage of the product-metal binding state. Asn51, Glu64, and Asp155 form hydrogen bonds with the product and block the product from moving away from the protein. Phe114 and Trp152 play a dual role of gating and guiding in the pocket of exit |
-, 752824 |