EC Number   |
General Information |
Reference |
|---|
    3.5.3.6 | malfunction |
ADI modulates the angiogenic activity of endothelial tip cells. By arginine depletion, ADI disturbs actin filament in endothelial tip cells, causing disordered migratory direction and decreased migration ability |
718810 |
| 3.5.3.6 | malfunction |
argininosuccinate synthetase-deficient SCLC cells demonstrate sensitivity to pegylated ADI (ADI-PEG20), which is associated with the induction of autophagy and caspasein-dependent cell death. Arginine deiminase-PEG20 treatment of ASS-negative SCLC xenografts causes significant, dose-dependent inhibition of tumour growth of both small and established tumours |
719195 |
| 3.5.3.6 | malfunction |
calcium-dependent histone-modifying enzymes whose activity is dysregulated in inflammatory diseases and cancer |
752353 |
| 3.5.3.6 | malfunction |
comparison of wild type with arcA (arginine deiminase) and arcC (carbamate kinase) defective mutants demonstrate that the Burkholderia pseudomallei arginine deiminase system is associated with survival in acid |
720333 |
| 3.5.3.6 | metabolism |
arginine catabolism |
-, 753440 |
| 3.5.3.6 | metabolism |
protein arginine deiminases are calcium-dependent histone-modifying enzymes whose activity is dysregulated in inflammatory diseases and cancer. PAD2 functions as an estrogen receptor (ER) coactivator in breast cancer cells via the citrullination of histone tail arginine residues at ER binding sites |
752353 |
| 3.5.3.6 | metabolism |
the ADI pathway comprises three sequential reactions: in the first step, ADI converts L-arginine to L-citrulline, ammonia and CO2. Then, the product citrulline is cleaved by ornithine transcarbamilase into ornithine and carbamoyl-phosphate in the second step, after which the latter is used by carbamate kinase to convert ADP to ATP followed by the spontaneous decomposition of carbamate into ammonia and CO2. Weissella halotolerans strain W22 combines ADI and ornithine decarboxylation pathways and converts arginine to putrescine |
-, 712262 |
| 3.5.3.6 | physiological function |
ADI induces apoptosis and G0/G1-phase arrest of SNU-1cells, which may contribute to the chemopreventive potential of lactic acid bacteria |
-, 711623 |
| 3.5.3.6 | physiological function |
ADI induces excessive synthesis of reactive oxygen species, and activates caspase 8-, but not caspase 9-, dependent apoptosis in endothelial cells |
718810 |
| 3.5.3.6 | physiological function |
the enzyme is involved in the energy production and defense of this protozoan parasite |
754195 |
