EC Number   |
General Information |
Reference |
|---|
    3.5.1.25 | malfunction |
mutants deficient in protein Lmo0956 reveal strikingly altered cell morphology, strongly reduced cell wall murein content and decreased sensitivity to cell wall hydrolase, mutanolysin and peptide antibiotic, colistin |
718709 |
| 3.5.1.25 | malfunction |
UDP-N-acetylglucosamine synthesis and bacterial growth (due to lack of N-acetylglucosamine utilization) is completely inhibited in N-acetylglucosamine 6-phosphate deacetylase disruption mutants |
-, 720819 |
| 3.5.1.25 | metabolism |
gene products of operon 150, consisting of three genes: lmo0956, lmo0957, and lmo0958, are necessary for the cytosolic steps of the amino-sugar-recycling pathway. The reverse reaction to Glc-N-6-P is catalyzed by GlmS |
718709 |
| 3.5.1.25 | metabolism |
N-acetylglucosamine-6-phosphate deacetylase (NagA) and glucosamine-6-phosphate deaminase (NagB) are branch point enzymes that direct amino sugars into different pathways |
-, 753578 |
| 3.5.1.25 | metabolism |
the enzyme NagA catalyzes a metabolic step that connects the glycolysis pathway with the peptidoglycan biosynthesis and the synthesis of cell wall macromolecules, overview |
754179 |
| 3.5.1.25 | more |
enzyme structure modeling, overview |
718709 |
| 3.5.1.25 | more |
involvement of both subunits in binding substrate by NagA. NagA requires two Zn2+ metal ions for activity and displays an unusual hysteretic behaviour, which may have a role in regulating flux at this step |
-, 753578 |
| 3.5.1.25 | more |
the GlcNAc6P complex structure discloses the precise mode of GlcNAc6P binding and the structural framework of the active site, including two divalent metals located in the alpha/beta binuclear site. Enzyme structure comparisons, overview |
754179 |
| 3.5.1.25 | physiological function |
cytoplasmic de-N-acetylase Lmo0956 is required for cell wall peptidoglycan and teichoic acid biosynthesis and is also essential for bacterial cell growth, cell division, and sensitivity to cell wall hydrolases and peptide antibiotics |
718709 |
| 3.5.1.25 | physiological function |
Lmo0956 protein is required for cell wall peptidoglycan and teichoic acid biosynthesis and is essential for bacterial cell growth, cell division, and sensitivity to cell wall hydrolases and peptide antibiotics. Lmo0956 and Lmo2108 are involved in the deacetylation of muropeptides that have been taken up into the bacterial cell |
718709 |
