EC Number   |
General Information |
Reference |
|---|
   3.5.1.109 | physiological function |
glucosylceramide sphingomyelin deacylase, is expressed in the skin of patients with atopic dermatitis, which plays an important role in ceramide deficiency (including acylceramides) in the stratum corneum |
711127 |
| 3.5.1.109 | physiological function |
high-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis. The enzyme is highly expressed in the epidermis of patients with atopic dermatitis, and competes with sphingomyelinase or beta-glucocerebrosidase for the common substrate sphingomyelin or glucosylceramide, which leads to the ceramide deficiency of the stratum corneum in atopic dermatitis |
712668 |
| 3.5.1.109 | physiological function |
the abnormal expression of sphingomyelin deacylase, which acts as a by-pass enzyme and competes with EC 3.1.4.12 (sphingomyelin phosphodiesterase) as well as EC 3.2.1.45 (glucosylceramidase) for N-acyl-sphingosylphosphorylcholine and D-glucosyl-N-acylsphingosine, respectively, is mainly responsible for the ceramide deficiency in patients with atopic dermatitis. The biogenesis of EC 3.1.4.12 (sphingomyelin phosphodiesterase) as well as EC 3.2.1.45 (glucosylceramidase) may be critical to the pathogenesis of atopic dermatitis |
712591 |
