EC Number |
General Information |
Reference |
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3.5.1.105 | evolution |
chitin deacetylases and chitooligosaccharides deacetylases [EC 3.5.1.105 (CODa)]. ChDas and CODa are a group of enzymes catalyzing the hydrolysis of acetamido groups of N-acetyl-D-glucosamine residues in chitin, chitosan and chitooligosaccharides, respectively. Both of these groups of enzymes are classified in the carbohydrate esterase family 4 (CE4) in the CAZY database |
-, 753650 |
3.5.1.105 | evolution |
chitin oligosaccharide deacetylase (COD) typically comprise two carbohydrate-binding domains (CBDs) and one polysaccharide deacetylase domain. In contrast, Shewanella baltica ATCC BAA-1091 COD (Sb-COD) has only one CBD, yet exhibits chitin-binding properties and substrate specificities similar to those of other CODs |
-, 753032 |
3.5.1.105 | evolution |
the enzyme belongs to carbohydrate esterase (CE) family 14 |
-, 745652 |
3.5.1.105 | evolution |
the enzyme belongs to the carbohydrate esterase family 14 |
-, 752555 |
3.5.1.105 | evolution |
the enzyme belongs to the carbohydrate esterase family 4. Amino acid residues that officiate as the metal ion-binding triad and general acidbase catalysts are generally conserved in other Zn-dependent deacetylases |
-, 733875 |
3.5.1.105 | evolution |
the enzyme is an evolutionarily conserved protein that belongs to the the YdjC family of proteins |
-, 734074 |
3.5.1.105 | evolution |
YDJC belongs to the YDJC superfamily and exerts deacetylase activity |
754966 |
3.5.1.105 | malfunction |
gene silencing of YDJC suppresses sphingosylphosphorylcholine (SPC)-induced events. YdjC overexpression induces the SPC-induced events. YdjC deacetylase dominant negative mutant (YDJCD13A) does not induce SPC-induced events. YDJC siRNA reduces ERK activation and overexpression of YDJC induces ERK activation. The siRNA of ERK1 or ERK2 suppresses YDJC-induced phosphorylation and reorganization of keratin 8 (K8), and migration and invasion |
754966 |
3.5.1.105 | metabolism |
deacetylated chitobiose and chitotriose provide the induction signal necessary for the activation of the ChbR regulator |
-, 734074 |
3.5.1.105 | metabolism |
diacetylchitobiose deacetylase works in the chitin degradation pathway in combination with glucosaminidase to hydrolyze diacetylchitobiose (GlcNAc2) to glucosamine (GlcN). First, the N-acetyl group of GlcNAc2 is catalyzed by Dac from the nonreducing end residue N-acetylglucosamine (GlcNAc) of GlcNAc2 and generates the product GlcN-GlcNAc, the product (GlcNGlcNAc) is then hydrolyzed by glucosaminidase following degradation into GlcN and GlcNAc. Finally, the resulting monomer GlcNAc is catalyzed by Dac to generate GlcN |
-, 752555 |