EC Number   |
General Information |
Reference |
|---|
   3.4.99.B1 | malfunction |
rce1-deficient cells are highly sensitive toward calcofluor white. Because rce1-deficient single mutants still exhibit a halo due to the activity of the remaining CaaX protease, they are almost indistinguishable from wild type cells. In rce1/ste24 double deletion mutants, no halos are visible |
-, 720412 |
| 3.4.99.B1 | malfunction |
retinal development proceeds normally in the absence of RAS-converting enzyme 1 (Rce1), but photoreceptor cells fail to respond to light and subsequently degenerate in a rapid fashion. Phosphodiesterase 6 is unable to be transported to the outer segments in Rce1-deficient photoreceptor cells |
720928 |
| 3.4.99.B1 | metabolism |
the deubiquitinating enzyme USP17 negatively regulates the activity of RCE1 |
712410 |
| 3.4.99.B1 | physiological function |
both Ras-like small GTPases RalA and RalB require Ras converting CAAX endopeptidase 1 (RCE1) for association with the plasma membrane, albeit not with endomembranes, and loss of RCE1 causes mislocalization as well as sustained activation of both RalA and RalB |
754117 |
| 3.4.99.B1 | physiological function |
Rce1 can bind with farnesyltransferase beta |
754247 |
| 3.4.99.B1 | physiological function |
RCE1 is essential for the intracellular trafficking of phosphodiesterase 6 and survival of photoreceptor cells |
720928 |
| 3.4.99.B1 | physiological function |
RCE1 is involved in Ras trafficking to the plasma membrane and the Ras/MEK/ERK pathway. USP17 regulation of growth is RCE1-dependent, overview |
712410 |
