EC Number   |
General Information |
Reference |
|---|
   3.4.24.B5 | malfunction |
inhibition of follicle ovulation, by the inhibitors roscovitine or CDK9-inhibitor II, is accompanied by the suppression of Mmp15 expression in the follicle. In follicles treated with the inhibitors, the formation of the phosphorylated nuclear progestin receptor (Pgr) is inhibited. Roscovitine treatment causes a reduction in the binding of Pgr to the promoter region of gene mmp15 |
753226 |
| 3.4.24.B5 | metabolism |
branching morphogenesis is thought to depend on the mobilization of the membrane-anchored matrix metalloproteinases MMP14 (MT1-MMP) and MMP15 (MT2-MMP), which drive epithelial cell invasion by remodeling the extracellular matrix and triggering associated signaling cascades. Different roles played by MMP14 or MMP15 in the mammary gland epithelial compartment and in development of mammary gland, overview. Whereas MMP14 promotes white fat-associated adipogenesis in the developing mammary gland, MMP15 serves as an endogenous suppressor of beige/brown fat production |
753384 |
| 3.4.24.B5 | metabolism |
MMP14 and MMP15 are involved in trophoblast invasion |
753776 |
| 3.4.24.B5 | physiological function |
enzyme MMP15 mainly play roles in extracellular matrix disassembly |
754240 |
| 3.4.24.B5 | physiological function |
metalloproteinase MMP15 (MT2-MMP) drives epithelial cell invasion by remodeling the extracellular matrix and triggering associated signaling cascades. It plays a role in mammary gland development. Transcriptome profiling reveals a key role for MMP14 and MMP15 in regulating mammary gland adipocyte differentiation. MMP15 differentially controls the formation of thermogenic brown fat. Neonatal mammary gland branching proceeds in the absence of MMP15, early mammary epithelial branching is Mmp15 independent |
753384 |
| 3.4.24.B5 | physiological function |
nuclear progestin receptor phosphorylation by Cdk9 is required for the expression of Mmp15, a protease indispensable for ovulation in Medaka. The enzyme MMP-15 is involved in follicle layer extracellular matrix hydrolysis |
753226 |
