EC Number   |
General Information |
Reference |
|---|
   3.4.24.B14 | evolution |
neprilysin-2 is also a zinc metalloendopeptidase belonging to the same M13 family as neprilysin |
733906 |
| 3.4.24.B14 | evolution |
sequence comparisons of NEP (EC 3.4.24.11) and NEP-2 |
754689 |
| 3.4.24.B14 | malfunction |
mice deficient for the NEP2 gene show significant elevations in total amyloid-beta peptide species in the hippocampus and brainstem/diencephalon (1.5fold). Increases in amyloid-beta peptide accumulation are more dramatic in NEP2 knockout mice crossbred with APP transgenic mice. In NEP/NEP2 double-knockout mice, amyloid-beta peptide levels are marginally increased (1.5 to 2fold), compared with NEP-/-/NEP2+/+ controls. Treatment of these double-knockout mice with phosphoramidon results in elevations of amyloid-beta peptide, suggesting that yet other NEP-like amyloid-beta peptide -degrading endopeptidases are contributing to amyloid-beta peptide catabolism |
717067 |
| 3.4.24.B14 | malfunction |
NEP2 knockout mice show reduced sperm function |
733906 |
| 3.4.24.B14 | malfunction |
reduced enzyme activity in association with mild-cognitive impaired subjects and Alzheimer's disease subjects regardless of sex |
733906 |
| 3.4.24.B14 | metabolism |
neprilysin-2 (NEP2) in the central nervous system controls Alzheimer's protein (amyloid-beta) deposition, and prevents its occurrence, while in the peripheral system, its closest homologue, neutral endopeptidase neprilysin (NEP, EC 3.4.24.11), regulates hypertension and heart related diseases |
754689 |
| 3.4.24.B14 | metabolism |
neprilysin-2 (NEP2), a NEP-like endopeptidase, cooperates with neprilysin (NEP, EC 3.4.24.11) to control amyloid-beta peptide levels in the brain |
733906 |
| 3.4.24.B14 | more |
enzyme splice variants and their involvement in amloid beta peptide cleavage, overview |
733906 |
| 3.4.24.B14 | more |
enzyme splice variants and their involvement in amyloid beta peptide cleavage, overview |
733906 |
| 3.4.24.B14 | more |
molecular dynamics (MD) simulations of NEP-2 and modelling, overview. For substrate and inhibitor binding, Arg661 and Zn694 are identified as the most conserved residues |
754689 |
