EC Number   |
General Information |
Reference |
|---|
   3.4.24.74 | physiological function |
enterotoxin plays an essential role in mucosal inflammation and upregulates lipocalin-2 expression in intestinal epithelial cells through the activation of mitogen-activated protein kinases and the activator protein-1 signaling pathway |
734594 |
| 3.4.24.74 | physiological function |
recombinant Bacteroides fragilis toxin (BFT, 5 nM) upregulates spermine oxidase in human colonic epithelial cell lines HT-29/c1 and T-84, resulting in spermine oxidase-dependent generation of reactive oxygen species and induction of gamma-H2A.x, a marker of DNA damage. BFT exposure did not increase spermidine/spermine-N1-acetyltransferase or N1-acetylpolyamine oxidase expression |
-, 720920 |
| 3.4.24.74 | physiological function |
role of BFT in human host beta-defensin 2 induction from intestinal epithelial cells, HT-29 and Caco-2, requiring the presence of NF-kappaB binding sites. Also binding of NF-kappaB to the hBD-2 promoter is required for the induction of the hBD-2 gene in BFT-stimulated intestinal epithelial cells, while AP-1 is not involved, regulation, overview. Heat-labile enterotoxin BFT plays an essential role in host mucosal inflammation |
708719 |
| 3.4.24.74 | physiological function |
the enzyme can destroy the tight junctions in intestinal epithelium by cleaving E-cadherin, resulting in release of beta-catenin and loss of tight junctions. Intestinal epithelial cells exposed to bacteroides fragilis enterotoxin regulate nuclear factor-kappaB activation and inflammatory responses through beta-catenin expression |
753807 |
| 3.4.24.74 | physiological function |
the enzyme contributes to anaerobic sepsis. The colonic epithelial barrier is an important target of the enzyme |
754860 |
| 3.4.24.74 | physiological function |
the enzyme plays an essential role in mucosal inflammation and affects the expression of ICAM-1 and monocytic adhesion to endothelial cells. Stimulation of HUVECs and rat aortic endothelial cells with Bacteroides fragilis enterotoxin results in the induction of ICAM-1 expression |
720158 |
| 3.4.24.74 | physiological function |
the enzyme stimulates intestinal secretion, resulting in epithelial damage and necrosis. The enzyme is a virulence factor of enterotoxigenic Bacteroides fragilis that accompanies blood stream infections. Outer surface-exposed enzyme causes epithelial cell contact disruption |
753653 |
