EC Number |
General Information |
Reference |
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3.4.24.70 | evolution |
the TOP isozymes contain the conserved His-Glu-XX-His (HEXXH) sequence of active-site residues and belong to the M3 family of metallopeptidases |
733035 |
3.4.24.70 | evolution |
the TOP isozymes contain the conserved His-Glu-XX-His (HEXXH) sequence of active-site residues and belong to the M3 family of metallopeptidases. TOP1 and TOP2 are located on opposite ends of chromosome 5 and share high homology, indicating the occurrence of a past intra-chromosomal duplication event |
734914 |
3.4.24.70 | malfunction |
plants with defective enzyme expression exhibit heightened resistance to exogenous salicylate treatment |
734914 |
3.4.24.70 | metabolism |
isozymes TOP1 and TOP2 are necessary for effector-triggered plant immunity via RPS2 and RPS4 resistance genes, and regulation of pathogen-triggered programmed cell death. TOP1 and TOP2 expression are coordinately regulated during pathogen-associated molecular pattern-triggered plant immunity |
734914 |
3.4.24.70 | physiological function |
the enzyme is a target for salicylic acid binding and participate in SA-mediated plant innate immunity. Both isozymes TOP1 and TOP2 seem to play a role in salicylic acid-dependent innate immunity, but through independent pathways |
733035 |
3.4.24.70 | physiological function |
the enzyme is a target for salicylic acid binding and participate in SA-mediated plant innate immunity. Both isozymes TOP1 and TOP2 seem to play a role in salicylic acid-dependent innate immunity, they are necessary for the immune response to avirulent pathogens. Isozyme TOP1 induces the augmentation of expression of isozyme TOP2 by the flagellin peptide flg22. Isozymes TOP1 and TOP2 are necessary for effector-triggered plant immunity via RPS2 and RPS4 resistance genes, and regulation of pathogen-triggered programmed cell death |
734914 |
3.4.24.70 | physiological function |
the enzyme is a target for salicylic acid binding and participate in SA-mediated plant innate immunity. Both isozymes TOP1 and TOP2 seem to play a role in salicylic acid-dependent innate immunity, they are necessary for the immune response to avirulent pathogens. Isozymes TOP1 and TOP2 are necessary for effector-triggered plant immunity via RPS2 and RPS4 resistance genes, and regulation of pathogen-triggered programmed cell death |
734914 |