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Results 1 - 10 of 13 > >>
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.64malfunction ablation of the enzyme not only affects processing of mitochondrial matrix proteins but also inhibits the import process itself 734654
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.64malfunction analysis of the mas1 mutant (temperature-sensitive mas1 mutant strain in which mitochondrial processing protease (MPP) is inactive when the cells are shifted to growth at nonpermissive temperature (37 °C)) reveales an increase in protein levels of nonprocessed mitochondrial proteins as well as an elevated membrane potential and increased oxygen consumption in mas1 mitochondria upon growth at nonpermissive temperature is observed. These findings might point toward a response in mas1 cells triggered to counterbalance the proteotoxic stress induced by MPP dysfunction -, 754485
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.64malfunction mutations in the substrate binding glycine-rich loop of the mitochondrial processing peptidase-alpha protein (PMPCA) cause a severe mitochondrial disease 753318
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.64malfunction reducing enzyme activity induces phosphatase and tensin homologue-induced kinase 1 accumulation at the mitochondrial surface, leading to Parkin recruitment and mitophagy 733730
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.64metabolism the enzyme plays a role in phosphatase and tensin homologue-induced kinase 1 (PINK1) import and mitochondrial quality control via the PINK1-Parkin pathway 733730
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.64metabolism the thylakoid-transfer signal is required for energy-dependent translocation of preproteins into the thylakoid lumen and is removed by the thylakoidal processing peptidase 733864
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.64metabolism yeast Nfs1 undergoes two steps of proteolytic processing: first it is cleaved by the mitochondrial processing peptidase, MPP, which removes its mitochondrial targeting sequence, and then it is cleaved by a peptidase, designated Icp55, which removes three amino acids from its N-terminus 709066
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.64more expression of mppA is developmentally regulated 709853
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.64physiological function most important processing enzyme that acts on proteins directed to the inner membrane intermembrane space or mitochondrial matrix. Most of the proteins targeted to the mitochondrial matrix or inner membrane present a single cleavage by mitochondrial processing peptidase 753580
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.64physiological function MPP is involved in the transport of nuclear-encoded proteins from the cytosol into mitochondria -, 710508
Results 1 - 10 of 13 > >>