EC Number   |
General Information |
Reference |
|---|
   3.4.23.45 | metabolism |
enzyme-mediated beta-cleavage of amyloid precursor protein is a mechanism underlying Alzheimer's disease pathogenesis |
754563 |
| 3.4.23.45 | metabolism |
the key step in the generation of Abeta is cleavage of APP by beta-secretase |
711696 |
| 3.4.23.45 | physiological function |
BACE2 colocalizes with clathrin-coated vesicles of the plasma membrane in MIN6 cells. Pharmacological inhibition of BACE2 results in increased BACE2 content in clathrin-coated vesicles, reduced insulin internalization rate, decreased in insulin receptor beta-subunit at the plasma membrane and increase in the Golgi apparatus, and a significant reduction in insulin gene expression. Similar results are obtained after specific BACE2 silencing in MIN6 cells. Data point to a role for BACE2 in the insulin receptor-beta subunit trafficking and insulin signaling |
717072 |
| 3.4.23.45 | physiological function |
BACE2 is highly expressed in pigment cells and homozygous Bace2 mutant mice display coat color defects, implying a specific role for BACE2 during melanogenesis |
735167 |
| 3.4.23.45 | physiological function |
in a mouse model of in vivo BACE2 overexpression, BACE2 is not involved in the amyloidogenic pathway, cognitive dysfunction or cholinergic degeneration. Transgenic BACE2 animals show increased anxiety-like behaviour along with increased numbers of noradrenergic neurones in locus coeruleus |
717636 |
| 3.4.23.45 | physiological function |
mice with functionally inactive Bace2 and insulin-resistant mice treated with a Bace2 inhibitor both display augmented beta cell mass and improved control of glucose homeostasis due to increased insulin levels |
717461 |
| 3.4.23.45 | physiological function |
mutations in Bace2 reveal a distinct melanocyte migration phenotype, which is not observed in homozygous Bace1 mutants. Double homozygous Bace1/Bace2 fish do not enhance the single mutant phenotypes indicating non-redundant distinct physiological functions. Single homozygous bace1 mutants as well as double homozygous bace1 and bace2 mutants are viable and fertile |
734521 |
