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EC Number	General Information	Commentary	Reference
3.4.23.40	metabolism	either the plant-specific insert domain or the C-terminal peptide VGFAEAA is necessary and sufficient to direct proteins to the vacuole. Both domains are vacuolar sorting determinants	734915
3.4.23.40	physiological function	epithelial A549 cell-bound cardosin A is internalized to endosomes and lysosomes and triggers the permeability of lysosomal membrane leading to apoptosis of the epithelial cells. The enzyme may have a defensive function against the ingestion of cardoon flowers by human, insects, and other herbivores	755355

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Release 2023.1 (January 2023)