EC Number   |
General Information |
Reference |
|---|
   3.4.22.B72 | evolution |
the enzyme is a member of the small ubiquitin-like modifier-specific protease family |
-, 731628 |
| 3.4.22.B72 | evolution |
the enzyme is a member of the SUMO-specific protease family |
-, 731627 |
| 3.4.22.B72 | malfunction |
depletion of SENP3 by short interfering RNA interferes with nucleolar ribosomal RNA processing and inhibits the conversion of the 32S rRNA species to the 28S form, thus phenocopying the processing defect observed on depletion of nucleophosmin 1 (NPM1) |
679510 |
| 3.4.22.B72 | malfunction |
downregulation of SENP3 increases Drp1 SUMO-2/3ylation and decreases its mitochondrial association, which reduces Drp1-dependent cytochrome c release via reduced mitochondrial fission and fragmentation. Depletion of enzyme SENP3 prolongs GTPase Drp1 SUMOylation, which suppresses Drp1-mediated cytochrome c release and caspase-mediated cell death. SENP3 levels recover following reoxygenation after oxygen/glucose deprivation allowing deSUMOylation of Drp1, which facilitates Drp1 localization at mitochondria and promotes fragmentation and cytochrome c release. RNAi knockdown of SENP3 protects cells from reoxygenation-induced cell death via a mechanism that requires Drp1 SUMOylation |
731711 |
| 3.4.22.B72 | malfunction |
expression of mesenchymal marker genes and cell migration ability are enhanced in SENP3-overexpressing gastric cancer cells and attenuated in SENP3-knockdown cells |
732595 |
| 3.4.22.B72 | malfunction |
in the absence of SENP3, the association of menin and Ash2L with the DLX3 geneis impaired, leading to decreased H3K4 methylation and reduced recruitment of active RNA polymerase II |
732510 |
| 3.4.22.B72 | malfunction |
upon depletion of SENP3 the amount of Borealin-SUMO2/3 conjugates is significantly increased |
716162 |
| 3.4.22.B72 | metabolism |
correlation between SENP3 expression and gastric cancer metastasis |
732595 |
| 3.4.22.B72 | metabolism |
molecular mechanisms of SUMOylation in the cellular response to oxygen/glucose deprivation, overview |
731711 |
| 3.4.22.B72 | more |
SENP3, a redox-sensitive SUMO2/3-specific protease |
732595 |
