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Results 1 - 4 of 4
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.B27malfunction epidermal growth factor receptor degradation is slightly delayed in CAPN7-knockdown HeLa cells, the effect can be reversed by re-expression of wild-type enzyme CAPN7 but not a protease-inactive mutant 731800
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.B27more calpain-7 is a unique intracellular cysteine protease that has a tandem repeat of microtubule interacting and trafficking domains and lacks a penta-EF-hand domain. The catalytic residues are C290, H458 and N478 731800
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.B27more importance of not only the N-terminal microtubule-interacting and trafficking domains but also the C-terminal C2 domain-like domains for proteolytic activity of the enzyme 731791
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.B27physiological function the enzyme is involved in membrane trafficking. The proteolytic activity of CAPN7 is important for the acceleration of epidermal growth factor receptor degradation via the endosomal sorting pathway utilizing a part of the endosomal sorting complex required for transport, ESCRT, system 731800
Results 1 - 4 of 4