EC Number   |
General Information |
Reference |
|---|
   3.4.22.B24 | malfunction |
deletion of calpain 4 leads to reduced chondrocyte proliferation and differentiation in embryonic growth plates. Deletion of calpain 4 in cells of the chondrocyte lineage correlated with impaired cell cycle progression at the G1/S transition, reduced cyclin D gene transcription |
718110 |
| 3.4.22.B24 | physiological function |
calpain 4 is a small regulatory calpain subunit required for expression and activity of ubiquitously expressed calpains 1 and 2 in CD4+ T cells. Calpain 4 is not required for T cell development and apoptosis. Calpain 4 is not necessary for LFA-1-mediated adhesion, conjugation or migration in CD4+ T cells |
710389 |
| 3.4.22.B24 | physiological function |
calpain 4 is essential for proper chondrocyte functions in embryonic growth plates |
718110 |
| 3.4.22.B24 | physiological function |
calpain 4 is essential for the secretion and tyrosine phosphorylation of galectin-3 |
717198 |
| 3.4.22.B24 | physiological function |
Capn4 as a regulatory subunit is essential for micro- and m-calpain activity, the upregulation of Capn4 mediated by HBx contributes to migration of hepatoma cells |
709489 |
