EC Number   |
General Information |
Reference |
|---|
   3.4.22.62 | evolution |
key structural and catalytic features are conserved across the entire family of cysteine-dependent aspartate-specific proteases (caspases) |
731760 |
| 3.4.22.62 | evolution |
members of the caspase family can be subdivided into initiator and effector caspases depending on their placement within the cascade of apoptosis signal transduction. Initiator caspases comprise caspase-2, -8, -9 and -10, which are capable of activating downstream caspases (executioners) after cleavage either directly through proteolysis or indirectly via a secondary messenger mechanism |
731215 |
| 3.4.22.62 | evolution |
multiple sequence alignment and phylogenetic tree show that fish and human caspase 9 are highly evolutionarily conserved |
717527 |
| 3.4.22.62 | malfunction |
caspase-9 inactivation by specific siRNA restrains the cleavage of Bcl-2 and Bcl-xL, inhibition of caspase-9 also prevents the degradation of Bcl-2 and Bcl-xL |
731609 |
| 3.4.22.62 | malfunction |
caspase-9 inhibition induces functional neuroprotection |
731960 |
| 3.4.22.62 | malfunction |
inhibition of caspase-9 activity results in unexpected, marked enhancement of cell death, inhibition of caspase-9 blocks the autophagic process by modulating lysosomal pH and acid-dependent cathepsin activities and augments cell death due to blockage of cytoprotective autophagy. Knockdown of caspase-9 expression by specific siRNA causes increased susceptibility to NSAID FR122047-induced cell death |
717277 |
| 3.4.22.62 | malfunction |
introduction of a dominant negative Casp9 inhibits mitochondrial remodeling without affecting the release of cytochrome c |
731550 |
| 3.4.22.62 | malfunction |
loss of caspase-9 results in increased DNA damage and mutation burden after exposure to alkylating agents. Casp9 deficiency results in decreased erythroid and B-cell progenitor abundance and impaired function of hematopoietic stem cells after transplantation. Loss of Casp9 alters hematopoietic progenitor cell frequency |
-, 731537 |
| 3.4.22.62 | metabolism |
activation of caspase-9 and caspase-3 via proteolytic cleavage is crucial for the regulation of the apoptotic program |
731452 |
| 3.4.22.62 | metabolism |
caspase-9 regulates Puma and caspase-3 activation in apoptosis in cancer cells |
731609 |
