EC Number   |
General Information |
Reference |
|---|
   3.4.22.59 | evolution |
the caspase-cleavage motifs in teleomerases from old world monkeys and apes, and the caspase-6 sites appear conserved in all primates |
717260 |
| 3.4.22.59 | malfunction |
caspase-6 down-regulation suppresses 7A6 localization to mitochondria |
752501 |
| 3.4.22.59 | malfunction |
caspase-6 inhibition or knockdown slows the progress of axon damage in serially imaged cutaneous nerves. Inhibition of caspase-6 delays neurofilament dissolution following nerve resection. Mice lacking Casp6 exhibit subtle delays in axonal degeneration |
754908 |
| 3.4.22.59 | malfunction |
gene deletion of caspase-6 did not affect the outcome of brain injury following mild (50 min) or severe (60 min) hypoxia-ischaemia |
731702 |
| 3.4.22.59 | malfunction |
the excess neuronal activity of Caspase-6 is associated with Alzheimer disease neuropathology and age-dependent cognitive impairment |
755524 |
| 3.4.22.59 | more |
the pro-Casp6b protein resulting from CASP6beta translation lacks part of the pro-domain and part of the large p20 subunit of pro-Casp6a |
717804 |
| 3.4.22.59 | physiological function |
alternatively activated macrophages play essential roles in the promotion of tissue remodeling, vasculogenesis, and tumor progression. Caspase-6 is a regulator of alternatively activated macrophages |
754137 |
| 3.4.22.59 | physiological function |
alternatively spliced caspase-6B isoform inhibits the activation of caspase-6A. Pro-Casp6b can negatively regulate pro-Casp6a activation in neurons and prevent Casp6a-mediated axonal degeneration. Pro-Casp6b inhibits RCasp1-mediated processing of Pro-Casp6a in vitro |
717804 |
| 3.4.22.59 | physiological function |
an exosite tri-arginine patch, 42RRR44, located within the disordered N-terminal domain on caspase-6 is critical for protein substrate recognition and turnover and therefore highly relevant for diseases such as cancer in which caspase-6-mediated apoptosis is often disrupted, and in neurodegeneration in which caspase-6 plays a central role |
754186 |
| 3.4.22.59 | physiological function |
caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment |
731604 |
