EC Number   |
General Information |
Reference |
|---|
   3.4.22.52 | malfunction |
calpain inhibition does not protect endothelial cells during cold storage |
709720 |
| 3.4.22.52 | malfunction |
calpain inhibition favors differentiation of neuronal stem cells. Calpain 1 silencing results in increased levels of both neuronal and glial markers, beta-III tubulin and glial fibrillary acidic protein |
732688 |
| 3.4.22.52 | malfunction |
calpain inhibition prevents NMDA-induced AIF truncation and nuclear translocation in neurons |
708434 |
| 3.4.22.52 | malfunction |
calpain-1 overactivation in mitochondrial-deficient cells promotes caspase-3 activation, calpain inhibition decreases alpha-synuclein oligomerization |
710069 |
| 3.4.22.52 | malfunction |
engineered cleavage of Rad21 at the calpain-cleavable site without activation of calpain-1 can lead to a loss of sister chromatid cohesion |
718111 |
| 3.4.22.52 | malfunction |
expression levels of galectin-3 are unchanged when calpain 1 is silenced |
717198 |
| 3.4.22.52 | malfunction |
immunodepletion or inhibition of calpain-1 in hypotonically lysed and resealed erythrocytes prevents the escape of Plasmodium falciparum parasites. Similarly, efficient egress of Tooplasma gondii from mammalian fibroblasts is blocked by either small interfering RNA-mediated suppression or genetic deletion of calpain activity |
710561 |
| 3.4.22.52 | malfunction |
in utero knockdown of calpain by shRNA rescues defective cortical layering in heterozygous Lis1+/? mice |
710042 |
| 3.4.22.52 | malfunction |
inhibition of micro-calpain not only significantly reduces caspase-9/-3 activities but also completely blocks apoptosis-inducing factor redistribution |
708761 |
| 3.4.22.52 | malfunction |
knocking down mu-calpain by siRNA in FA-A cells restores levels of alphaII-spectrin to normal and reverses a number of the cellular deficiencies in these cells. siRNA knockdown of mu-Calpain in FA-A cells leads to increased cell viability and formation of nuclear foci after damage with a DNA interstrand cross-linking agent |
707532 |
