EC Number   |
General Information |
Reference |
|---|
   3.4.21.B41 | evolution |
the enzyme is a member of the human kallikrein gene family of secreted serine proteases |
731898 |
| 3.4.21.B41 | malfunction |
KLK10 hypermethylation is significantly associated with cirrhosis and HCV infection as well as inversely associated with HBV infection. Restoration of KLK10 expression, by 5-aza-cytidine treatment, reduces the ability of anchorage-independent growth, and sensitizes hepatocellular carcinoma cells to doxorubicin- or 5-fluorouracil-induced cytotoxicity |
708585 |
| 3.4.21.B41 | metabolism |
multiple mechanisms account for enzyme KLK10 dysregulation in cancer including hypermethylation, and the frequent inactivation and loss of KLK10 expression is a critical step towards carcinogenesis |
732959 |
| 3.4.21.B41 | metabolism |
the enzyme is mplicated in the development of several types of cancer. A kallikrein cascade may play a role in the development and/or outcome of some salivary gland tumours, overview |
731941 |
| 3.4.21.B41 | more |
significant correlation between KLK6 and KLK10 expression both at the invasive front and within the main tumor, indicating a collaborative effect |
731898 |
