EC Number   |
General Information |
Reference |
|---|
   3.4.21.B24 | evolution |
proprotein convertase 4 is a member of a family of proprotein convertases that convert inactive precursor proteins into their mature and active forms |
732513 |
| 3.4.21.B24 | evolution |
the enzyme belongs to the 9-member superfamily of mammalian subtilases collectively called proprotein convertases or proprotein convertase subtilisin/kexins that convert inactive precursor proteins into their active mature forms by endoproteolytic cleavage |
731692 |
| 3.4.21.B24 | malfunction |
inactivation of its gene in mouse does not alter spermatogenesis, but renders sperm incapable of fertilizing oocytes, resulting in part from sperm susceptibility to a premature acrosome reaction and from reduced ability to bind to the zona pellucida. In female mice, a lack of PCSK4 causes subfertility associated with impaired folliculogenesis |
692581 |
| 3.4.21.B24 | malfunction |
PC4 knockout mice exhibit severely impaired male fertility due to premature sperm acrosome reaction |
731692 |
| 3.4.21.B24 | physiological function |
PC4 activates everal protein precursors in the secretory pathway of mammalian reproduction system with a vital role in fertilization and sperm maturation |
707011 |
| 3.4.21.B24 | physiological function |
the enzyme activity plays a crucial role in mammalian fertilization via activation of sperm surface proteins |
731692 |
| 3.4.21.B24 | physiological function |
the enzyme belongs to a family of endoproteinases involved in the proteolytic conversion of secretory precursor proteins to their active forms. PCSK4 appears to be a crucial enzyme for reproduction |
692581 |
| 3.4.21.B24 | physiological function |
the enzyme belongs to a family of endoproteinases involved in the proteolytic conversion of secretory precursor proteins to their active forms. PCSK4 appears to be a crucial enzyme for reproduction. It stimulates the invasiveness of human placental trophoblasts in culture, suggesting that it may facilitate placentation in vivo |
692581 |
| 3.4.21.B24 | physiological function |
the enzyme is linked to mammalian fertilization and placenta growth |
752978 |
