EC Number   |
General Information |
Reference |
|---|
   3.4.21.B21 | malfunction |
inactivation of dentilisin abolishes the coaggregation activity |
-, 731118 |
| 3.4.21.B21 | physiological function |
negative complement regulatory protein factor H bound to the FhbB protein on the surface of Treponema denticola cell curface to avoid complement-mediated cell killing. The enzyme activity triggers localized dysregulation of complement activation in periodontal pockets |
732538 |
| 3.4.21.B21 | physiological function |
the enzyme dentilisin is a surface protease complex that has a significant role in Treponema denticola-host interactions in periodontal disease |
-, 732535 |
| 3.4.21.B21 | physiological function |
the enzyme is involved in biofilm formation and, within a high-molecular-mass complex on the cell surface, mediates adherence of Treponema denticola to other potential periodontal pathogens, Porphyromonas gingivalis, Fusobacterium nucleatum, Prevotella intermedia, and Parvimonas micra. The enzyme's protease activity is not required for the interaction, but the enzyme expression is critical for dual-species biofilm formation, overview |
-, 732466 |
| 3.4.21.B21 | physiological function |
the enzyme is required for formation of the so called Red complex between Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia, although the protease activity of the enzyme is not necessary. Treponema denticola strain ATCC 33520 shows low level of coaggregation |
-, 731118 |
| 3.4.21.B21 | physiological function |
the enzyme is required for formation of the so called Red complex between Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia, although the protease activity of the enzyme is not necessary. Treponema denticola strain ATCC 33521 shows only a trace level of coaggregation |
-, 731118 |
| 3.4.21.B21 | physiological function |
the enzyme is required for formation of the socalled Red complex between Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia, although the protease activity of the enzyme is not necessary. Treponema denticola strain ATCC 35405 shows a higher level of coaggregation |
-, 731118 |
| 3.4.21.B21 | physiological function |
Treponema denticola acylated outer membrane PrtP protease complex induces both activation of MMP-2 and generation of fibronectin fragments in human PDL cell culture supernatants |
-, 717662 |
