EC Number   |
General Information |
Reference |
|---|
   3.4.21.B10 | evolution |
the enzyme is a member of the human kallikrein gene family of secreted serine proteases |
731898 |
| 3.4.21.B10 | malfunction |
ERK1/2 signaling in cerebellar granule neurons and in the NSC34 spinal cord motoneuron cell line is reduced by lipopeptide inhibitors of PAR1 or PAR2, and PAR1 genetic deletion, which reduces the neurotoxic effects of the enzyme |
-, 732361 |
| 3.4.21.B10 | malfunction |
KLK6 knockout mice have thinner epidermis and decreased keratinocyte proliferation. The keratinocytes in wild type and KLK6 knockout epidermis are equally sensitive to acute anti-proliferative effect of fluocinolone acetonide. The development of proliferative resistance during chronic treatment is reduced in knockout epidermis |
754955 |
| 3.4.21.B10 | malfunction |
KLK6-deficient primary cortical neurons have increased ability for alpha-synuclein fibril uptake |
754959 |
| 3.4.21.B10 | metabolism |
kallikrein 6 and thrombin are important regulators of neural pathophysiology and neurotoxic |
-, 732361 |
| 3.4.21.B10 | metabolism |
KLK6 can be a major player in the turnover of alpha-synuclein species |
754959 |
| 3.4.21.B10 | metabolism |
mechanism of epidermal regeneration after glucocorticoid-induced atrophy via KLK6 activation |
754955 |
| 3.4.21.B10 | more |
brain-targeted neurosin accumulates throughout the CNS in neurons, astrocytes and microglia, and results in reduced accumulation of alpha-synuclein in oligodendrocytes and astrocytes with possible clearance via microglia. It also ameliorates myelin degeneration, neuropathology and behavioral deficits. The modified, brain-targeted neurosin may warrant further investigation as potential therapy for multiple system atrophy |
754778 |
| 3.4.21.B10 | more |
Klk6 and the prototypical activator of protease activated receptor 1, PAR1, thrombin, as well as PAR1 and PAR2, are each elevated in murine experimental traumatic spinal cord injury at acute or subacute time points |
-, 732361 |
| 3.4.21.B10 | more |
significant correlation between KLK6 and KLK10 expression both at the invasive front and within the main tumor, indicating a collaborative effect |
731898 |
