EC Number   |
General Information |
Reference |
|---|
   3.4.21.94 | malfunction |
PC2 activity is reduced in ischemic brains, brain ischemia attenuates PC2 and PC2-mediated neuropeptide processing. This attenuation may play a role in the pathology of ischemic brain injury. Intracerebroventricular administration of synthetic PC2 substrate dynorphin-A(1-8) significantly reduces the extent of ischemic brain injury, overview |
709250 |
| 3.4.21.94 | metabolism |
prohormone convertase 2 belongs to a family of enzymes involved in the proteolytic maturation of neuropeptide precursors into mature peptides that act as neurotransmitters, neuromodulators or neurohormones |
708778 |
| 3.4.21.94 | physiological function |
in wolframin knockout mice, the activity of PC2 in hippocampus is significantly increased, while the protein levels of proPC2 and PC2 and of chaperone secretogranin are unchanged. The processing of proSAAS and proenkephalin is altered in the hippocampus of wolframin knockout mice |
753696 |
| 3.4.21.94 | physiological function |
PC2 expression and Akt phosphorylation are related at the molecular level, resulting in a change in cell cycle and an increase in pituitary adenoma size |
717906 |
| 3.4.21.94 | physiological function |
PC2 functions in the generation of neuropeptides from their precursors, of neuropeptides/secretory pathway proteins, quantitative peptidomics, overview. Role of PC2 in the processing of peptides in a variety of brain regions |
709603 |
| 3.4.21.94 | physiological function |
PC2 is required for the neuropeptide pro-protein processing system |
710101 |
| 3.4.21.94 | physiological function |
PC2 mediates neuropeptide processing in the brain |
709250 |
| 3.4.21.94 | physiological function |
proglucagon cleavage has a greater dependence on PC2 activity than other precursors (e.g. proopiomelanocortin) and 7B2-dependent routing of PC2 to secretory granules is cell line-specific |
717856 |
