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EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.110more immunization of BALB/c mice with the recombinant enzyme can elicit a significant humoral antibody response and can confer significant protection against challenge with a lethal dose of Streptococcus zooepidemicus -, 732903
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.110physiological function complement components C3 and C3a are substrates for peptidase C5a. Both are functionally inactivated as a result of cleavage 7 amino acids upstream of the natural C3 convertase. Cleavage of C3a by C5a results in disruption of human neutrophil activation, phagocytosis and chemotaxis, while cleavage of C3 generates abnormally-sized C3a and C3b moieties with impaired function, in particular reducing C3 deposition on the bacterial surface. Expression of C5a reduces clearance of group A streptococci in vivo in wild-type and C5 deficient mice, and promotes systemic bacterial dissemination in mice that lack both C3 and C5 755210
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.110physiological function the purified recombinant SEZ C5a peptidase adheres to Hep-2 cells and interferes with the invasion of SEZ into Hep-2 cells -, 732903
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