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Results 1 - 10 of 11 > >>
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.14.10evolution the enzyme belongs to the peptidase S8 family. TY-21 TPP shows no homology with mammalian TPPII, but shows relatively higher homology with TPP S (49%). Alignment of the protein sequences of TY-21 TPP with TPP S and subtilisin reveal three conserved regions around the catalytic triad in the active site in these enzymes that are specific for subtilisin -, 752530
Display the word mapDisplay the reaction diagram Show all sequences 3.4.14.10malfunction cell lines from primary fibroblasts are generated having conditional (floxed) TPPII alleles, transformed with both the c-myc and H-ras oncogenes. TPPII is deleted using retroviral self-deleting Cre recombinase. Clonally derived TPPIIflox/flox and TPPII-/- transformed fibroblasts show no influences of TPPII expression on basal cell survival and proliferation, nor on radiation-induced p53 activation, p21 induction, cell cycle arrest, apoptosis, or clonogenic cell death 707371
Display the word mapDisplay the reaction diagram Show all sequences 3.4.14.10malfunction suppression of TPP2 expression with shRNA significantly inhibits cellular proliferation compared with the control cells 732216
Display the word mapDisplay the reaction diagram Show all sequences 3.4.14.10physiological function in the absence of proteasome inhibitor BSc2118, TPPII is diffusely dispersed within the cytoplasm of C-26 colon adenocarcinoma cells. The proteasome and ubiquitin-rich perinuclear region do not display enhanced TPPII staining. When proteasome function is impaired by the inhibitor, TPPII associates more closely with both the proteasome and polyubiquitinated. TPPII is dynamically recruited into the developing aggresome: TPPII in the early aggresome is dispersed within the central part but subsequently aggregated on the surface of this structure 753768
Display the word mapDisplay the reaction diagram Show all sequences 3.4.14.10physiological function isoform TPPII can regulate sperm maturation by modulating intracellular Ca2+ stores via the type 3 ryanodine receptor. Tripeptidyl peptidase II antagonists strongly activate the cAMP/PKA signaling pathway that drives sperm capacitation-associated protein tyrosine phosphorylation. In the absence of Ca2+, TPPII antagonists elevate the intracellular Ca2+ levels in sperm, resulting in a marked improvement in sperm movement, capacitation, acrosome reaction, and the in vitro fertilizing ability. This antagonist-induced release of intracellular Ca2+ can be blocked by the inhibitors of ryanodine receptors which are the main intracellular Ca2+ channels responsible for releasing stored Ca2+ 732731
Display the word mapDisplay the reaction diagram Show all sequences 3.4.14.10physiological function isoform TPPII physically interacts with the tumor suppressor MYBBP1A and the cell cycle regulator protein CDK2. HEK-293 cells overexpressing TPPII form highly enzymatically active oligomeric complexes, and the cytoplasmic interaction frequency of TPPII with MYBBP1A increases with the protein expression of TPPII in serum-free cell growth conditions. A specific reversible inhibitor of TPPII, butabindide, suppresses the cytoplasmic interactions of TPPII and MYBBP1A both in control HEK-293 and cells overexpressing murine TPPII. A gene expression study during anoikis shows that overexpression of TPP II decreases mRNA expression level of MYBBP1A at the cell detachment conditions 731223
Display the word mapDisplay the reaction diagram Show all sequences 3.4.14.10physiological function it is demonstrated that both, the proteasome and TPPII play a role in the processing of Listeria monocytogenes-derived antigenic peptides 709833
Display the word mapDisplay the reaction diagram Show all sequences 3.4.14.10physiological function TPP II is involved in the fertilization process. The increased intercellular Ca2+ level induced by TPPII antagonists via RyR3 (ryanodine receptor) represents a mechanism of activation of sperm 732731
Display the word mapDisplay the reaction diagram Show all sequences 3.4.14.10physiological function TPP2 inhibition indirectlybut rapidly decreases the levels of active, diphosphorylated extracellular signal-regulated kinase ERK1 and ERK2 in the nucleus, thereby down-regulating signal transduction downstream of growth factors and mitogenic stimuli. TPP2 inhibition of neurons in the hippocampus leads to an excessive strengthening of synapses 754735
Display the word mapDisplay the reaction diagram Show all sequences 3.4.14.10physiological function TPPII, assembles to form a spindle-shaped complex of about 6 MDa. Dependent on protein concentration, TPPII has a distinct tendency for polymorphism. Two different assembly states (36-mers and 32-mers) coexist as well as occasional extended forms with longer strands. TPPII and 26S proteasomes spatially associate in agreement with TPPII's role in postproteasomal degradation 755260
Results 1 - 10 of 11 > >>