EC Number |
General Information |
Reference |
---|
3.2.2.29 | malfunction |
enzyme knockdown by shRNAs inhibits the proliferation of colorectal cancer cells in vitro and in vivo |
732173 |
3.2.2.29 | malfunction |
enzyme knockdown in melanoma cell lines causes cell cycle arrest, senescence, and death by mitotic alterations, alters the transcriptome and methylome, and impairs xenograft tumor formation |
751763 |
3.2.2.29 | malfunction |
enzyme-knockdown cells exhibit higher resistance to cell death caused by the induction of etheno-DNA adducts, lower repair activityfor 3,N4-ethenocytosine, and a modest acceleration of mutations caused by 3,N4-ethenocytosine,compared with the rate in control cells |
731862 |
3.2.2.29 | malfunction |
the enzyme interacts with the CH3 domain of histone acetyltransferase p300 to allosterically promote p300 activity to specific lysines on histone H3 (K18 and K23). The absence of the enzyme in mouse embryonic fibroblasts leads to a reduction in the rate of histone acetylation |
749910 |
3.2.2.29 | more |
opposing roles of CBP/p300 and PKCalpha in regulating the DNA repair functions of TDG, the interplay of acetylation and phosphorylation of TDG in vivo may be critically important in the maintenance of CpG dinucleotides and epigenetic regulation |
710145 |
3.2.2.29 | physiological function |
ectopic enzyme expression compromises cellular survival after UV irradiation and repair of UV-induced DNA lesions |
750696 |
3.2.2.29 | physiological function |
TDG plays an integral role in CpG maintenance by excising mispaired thymine and uracil in a CpG context and also participates in transcriptional regulation via gene-specific CpG demethylation and functional interactions with the transcription machinery |
710145 |
3.2.2.29 | physiological function |
TDG seems not to have an important function in uracil repair compared with the leading enzymes UNG2 and SMUG1, EC 3.2.2.27 |
710229 |
3.2.2.29 | physiological function |
the enzyme does not affect HBV replication, but the hepatitis B virus X-protein strongly inhibits enzyme-initiated base excision repair |
732708 |
3.2.2.29 | physiological function |
the enzyme functions in base excision repair and also acts as a key enzyme that participates in active DNA demethylation. Aberrant enzyme expression causes epigenetic modifications and meiotic cell cycle arrest of mouse oocytes |
732514 |